ArticleCancers2018
FRoG-A New Calculation Engine for Clinical Investigations with Proton and Carbon Ion Beams at CNAO.
Article in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Deep learning-based prediction of Monte Carlo dose distribution for heavy ion therapy.Physics and imaging in radiation oncology · 2025Article
- Development and benchmarking of a dose rate engine for raster-scanned FLASH helium ions.Medical physics · 2024Article
- Review
- Creation, evolution, and future challenges of ion beam therapy from a medical physicist's viewpoint (Part 2). Chapter 2. Biophysical model, treatment planning system and image guided radiotherapy.Radiological physics and technology · 2023Review
- Validation of the relative biological effectiveness of active-energy scanning carbon-ion radiotherapy on a commercial treatment planning system with a microdosimetic kinetic model.Radiation oncology (London, England) · 2023Article
- Calculating dose-averaged linear energy transfer in an analytical treatment planning system for carbon-ion radiotherapy.Journal of applied clinical medical physics · 2023Article
- Article
- How can we consider variable RBE and LETRadiation oncology (London, England) · 2022Article
- Evaluation of radiophotoluminescent glass dosimeter response for therapeutic spot scanning proton beam: suggestion of linear energy transfer-based correction.Journal of applied clinical medical physics · 2021Article
- A Modular System for Treating Moving Anatomical Targets With Scanned Ion Beams at Multiple Facilities: Pre-Clinical Testing for Quality and Safety of Beam Delivery.Frontiers in oncology · 2021Article
- Treatment planning for proton therapy: what is needed in the next 10 years?The British journal of radiology · 2020Review
- Adenoid Cystic Carcinoma of the Lacrimal Gland: High Dose Adjuvant Proton Therapy to Improve Patients Outcomes.Frontiers in oncology · 2020Article
- Article
- Biophysical modeling and experimental validation of relative biological effectiveness (RBE) forRadiation oncology (London, England) · 2019Article
- Spot-Scanning Hadron Arc (SHArc) Therapy: A Study With Light and Heavy Ions.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A fast and accurate dose calculation engine for hadrontherapy is critical for both routine clinical and advanced research applications. FRoG is a graphics processing unit (GPU)-based forward calculation tool developed at CNAO (Centro Nazionale di Adroterapia Oncologica) and at HIT (Heidelberg Ion Beam Therapy Center) for fast and accurate calculation of both physical and biological dose. FRoG calculation engine adopts a triple Gaussian parameterization for the description of the lateral dose distribution. FRoG provides dose, dose-averaged linear energy transfer, and biological dose-maps, -profiles, and -volume-histograms. For the benchmark of the FRoG calculation engine, using the clinical settings available at CNAO, spread-out Bragg peaks (SOBPs) and patient cases for both proton and carbon ion beams have been calculated and compared against FLUKA Monte Carlo (MC) predictions. In addition, FRoG patient-specific quality assurance (QA) has been performed for twenty-five proton and carbon ion fields. As a result, for protons, biological dose values, using a relative biological effectiveness (RBE) of 1.1, agree on average with MC within ~1% for both SOBPs and patient plans. For carbon ions, RBE-weighted dose (D
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