ArticleMolecules (Basel, Switzerland)2018
The Radiostability of Meropenem Trihydrate in Solid State.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- How Does Radiation Affect Curcumin Raw Material?International journal of molecular sciences · 2024Article
- Do Rutin and Quercetin Retain Their Structure and Radical Scavenging Activity after Exposure to Radiation?Molecules (Basel, Switzerland) · 2023Article
- Antioxidant Potential of Resveratrol as the Result of Radiation Exposition.Antioxidants (Basel, Switzerland) · 2022Article
- Electron Beam Radiation as a Safe Method for the Sterilization of Aceclofenac and Diclofenac-The Usefulness of EPR andPharmaceutics · 2022Article
- Elution and Biomechanical Properties of Meropenem-Loaded Bone Cement.Orthopaedic surgery · 2021Article
- The Radiation Sterilization of Ertapenem Sodium in the Solid State.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
9 authors.
Funding
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Abstract
The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No changes for meropenem irradiated with a dose of 25 kGy, the dose required to attain sterility, was confirmed in the results of spectroscopic (FT-IR), thermal (DSC, TGA) and X-ray powder diffraction (XRPD) studies. The radiation dose of 25 kGy produces no more than about 1500 ppm of radical defects. The chromatographic studies of irradiated meropenem in solutions did not show any chemical degradation. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Based on the received results, we can conclude that radiostelization is a promising, alternative method for obtaining sterile meropenem. In the second part of the research, meropenem was exposed to e-beam radiation at the 400 kGy dose rate. It was confirmed, that reducing of antimicrobial activity could be connected with the degradation of β-lactam ring and changes in the trans-hydroxyethyl group. Apart from chemical changes, changes in the physical stability of irradiated meropenem (400 kGy) was also observed.
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