ArticleMetabolites2018
Partial Least Squares Discriminant Analysis and Bayesian Networks for Metabolomic Prediction of Childhood Asthma.
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In one paragraph
Article in Metabolites, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 29% of its field
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Opportunities and challenges with artificial intelligence in allergy and immunology: a bibliometric study.Frontiers in medicine · 2025Pooled it
- Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma.EBioMedicine · 2024Pooled it
- A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed.Nature communications · 2023Trial
- Study on the Therapeutic Effects of Ginsenoside Rh2 in Asthma Improvement.International journal of molecular sciences · 2026Article
- Fueling asthma inflammation via bioenergetic metabolic reprogramming.Redox biology · 2026Article
- Integrated genomic, transcriptomic, and metabolomic profile analysis reveals molecular mechanism underlying meat quality traits in Chinese Kangle chickens.Food chemistry. Molecular sciences · 2026Article
- The association of newborn metabolites with early-life wheezing and asthma among US children in the ECHO Program.Communications medicine · 2026Article
- Article
- Artificial intelligence in pediatric allergy research.European journal of pediatrics · 2024Review
- Consistent Multi-Omic Relationships Uncover Molecular Basis of Pediatric Asthma IgE Regulation.medRxiv : the preprint server for health sciences · 2024Article
- Characteristics of intestinal bacteriophages and their relationship with Bacteria and serum metabolites during quail sexual maturity transition.BMC veterinary research · 2024Article
- Inflammatory factors and risk of lung adenocarcinoma: a Mendelian randomization study mediated by blood metabolites.Frontiers in endocrinology · 2024Article
- Amino Acid Profiling Identifies Disease-Specific Signatures in IgE-Mediated and Non-IgE-Mediated Food Allergy in Pediatric Patients with Atopic Dermatitis.Biomedicines · 2023Article
- Statistical methods and resources for biomarker discovery using metabolomics.BMC bioinformatics · 2023Review
- Characteristics and potential biomarkers of flavor compounds in four Chinese indigenous chicken breeds.Frontiers in nutrition · 2023Article
- Identifying biomarkers of the gut bacteria, bacteriophages and serum metabolites associated with three weaning periods in piglets.BMC veterinary research · 2022Article
- Overview of Metabolomic Analysis and the Integration with Multi-Omics for Economic Traits in Cattle.Metabolites · 2021Review
- Metabolomics-Guided Elucidation of Plant Abiotic Stress Responses in the 4IR Era: An Overview.Metabolites · 2021Review
- The Effects of Indoor Pollutants Exposure on Allergy and Lung Inflammation: An Activation State of Neutrophils and Eosinophils in Sputum.International journal of environmental research and public health · 2020Article
- Alterations in Serum-Free Amino Acid Profiles in Childhood Asthma.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Rachel S KellyChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. hprke@channing.harvard.edu.ORCID 0000-0003-3023-1822
Michael J McGeachieChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. remmg@channing.harvard.edu.
Kathleen A Lee-SarwarChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. klee-sarwar@bwh.harvard.edu.
Priyadarshini KachrooChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. reprk@channing.harvard.edu.ORCID 0000-0002-5807-1333
Su H ChuChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. rechu@channing.harvard.edu.
Yamini V VirkudChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. YVIRKUD@mgh.harvard.edu.
Mengna HuangChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. remhu@channing.harvard.edu.
Augusto A LitonjuaChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. augusto_litonjua@urmc.rochester.edu.ORCID 0000-0003-0422-5875
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. restw@channing.harvard.edu.
Jessica Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. rejas@channing.harvard.edu.
Brigham and Women's Hospital · US
Funding
SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6MSystems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BARABASI, ALBERT-LASZLO · 2016 to 2020
$12.6MIMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2MRandomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood AsthmaU01HL091528 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2009 to 2013
$10.0MIntegrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0MAsthma Exacerbations and MicroRNA prediction: Treatment Response in an Underserved Ethnicity (AEM-TRUE)R01HL139634 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCGEACHIE, MICHAEL JOHN · 2018 to 2022
$4.3MThe Functional Consequences of the 17q12 Asthma Susceptibility LocusR01HL123546 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER · 2015 to 2018
$3.4MPHARMACOLOGY AND TOXICOLOGY OF ANTITUMOR AGENTSK04CA001012 · NCI · YALE UNIVERSITY · PI LAZO, JOHN S · 1985 to 1989
–National Centers for Advancing Translational Sciences U54TR001012National Heart, Lung, and Blood Institute 1R01HL123546-01A1National Heart, Lung, and Blood Institute 1R01HL123915-01National Heart, Lung, and Blood Institute 5R01HL123915-05National Heart, Lung, and Blood Institute R01 HL139634National Heart, Lung, and Blood Institute U01HL091528National Institute of Allergy and Infectious Diseases 5T32AI007306-30NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL139634NHLBI NIH HHS T32 HL007427U.S. Department of Defense W81XWH-17-1-0533
Abstract
To explore novel methods for the analysis of metabolomics data, we compared the ability of Partial Least Squares Discriminant Analysis (PLS-DA) and Bayesian networks (BN) to build predictive plasma metabolite models of age three asthma status in 411 three year olds (
Indexed as
arginine metabolismasthmaBayesian networksoverfittingPartial Least-Squares Discriminant analysis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.