Evidence map›Paper›PMID 30360486›Full record

ArticleInternational journal of molecular sciences2018

Loss of

Honglai Zhang, Rork Kuick, Sung-Soo Park, Claire Peabody, Justin Yoon, Ester Calvo Fernández, Junying Wang, Dafydd Thomas, Benoit Viollet, Ken Inoki and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. AMP-Activated Protein Kinase Signalling.International journal of molecular sciences · 2019
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Honglai ZhangDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. honglaiz@med.umich.edu.
Rork KuickDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA. rork@umich.edu.
Sung-Soo ParkDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. parksung@med.umich.edu.
Claire PeabodyDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. peabodyc@umich.edu.
Justin YoonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. jxy673@case.edu.
Ester Calvo FernándezDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. esfernan@med.umich.edu.
Junying WangLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. wangjoy03@gmail.com.
Dafydd ThomasDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. thomasda@med.umich.edu.
Benoit ViolletInserm, U1016, Institut Cochin, 75014 Paris, France. benoit.viollet@inserm.fr.ORCID 0000-0002-0121-0224
Ken InokiLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. inokik@umich.edu.ORCID 0000-0001-8882-444X
Sandra Camelo-PiraguaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. sandraca@med.umich.edu.
Jean-François RualDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. jrual@med.umich.edu.ORCID 0000-0003-4465-8819
University of Michigan · USDélégation Paris 5 · FR

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Role of TSC-mTORC1 pathway for podocyte injury in diabetic nephropathyR01DK083491 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI INOKI, KEN · 2009 to 2017
$3.0M
MCubed, University of Michigan MCubed GrantMichigan Institute for Clinical and Health Research UL1TR000433NCATS NIH HHS UL1 TR002240NIDDK NIH HHS R01 DK083491NIH HHS P30 CA046592NIH HHS RO1 DK083491NIH HHS RO1 GM110019St. Baldrick's Foundation St. Baldrick's Staff Giving Campaign Summer FellowshipUniversity of Michigan Rogel Cancer Center Padnos Fund for Innovative Cancer Research
6 · The paper itself

Abstract

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that has a dual role in cancer, i.e., pro- or anti-tumorigenic, depending on the context. In medulloblastoma, the most frequent malignant pediatric brain tumor, several in vitro studies previously showed that AMPK suppresses tumor cell growth. The role of AMPK in this disease context remains to be tested in vivo. Here, we investigate loss of

Indexed as

AMP-Activated Protein KinasesAnimalsBlotting, WesternCarcinogenesisGene DosageHedgehog ProteinsImmunohistochemistryMedulloblastomaMiceRNA-Binding ProteinsSignal TransductionAMP-Activated Protein KinasesCnbp protein, mouseHedgehog ProteinsPrkaa2 protein, mouseRNA-Binding ProteinsAMPKmedulloblastomasonic hedgehog

Identifiers

PMID30360486
PMCPMC6274763
OpenAlexW2896324864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.