Evidence map›Paper›PMID 30360481›Full record

ArticleMarine drugs2018

Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model.

Hye Won Lee, Su Mi Lee, Mi Hwa Lee, Young Ki Son, Seong Eun Kim, Won Suk An

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Frontiers in pharmacology · 2021
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hye Won LeeDepartment of Internal Medicine, Dong-A University, Busan 49201, Korea. lubhyewon@naver.com.
Su Mi LeeDepartment of Internal Medicine, Dong-A University, Busan 49201, Korea. promise131@hanmail.net.
Mi Hwa LeeDepartment of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, Dong-A University, Busan 49315, Korea. hero15p@nate.com.
Young Ki SonDepartment of Internal Medicine, Dong-A University, Busan 49201, Korea. kidney@dau.ac.kr.
Seong Eun KimDepartment of Internal Medicine, Dong-A University, Busan 49201, Korea. sekim@dau.ac.kr.
Won Suk AnDepartment of Internal Medicine, Dong-A University, Busan 49201, Korea. anws@dau.ac.kr.ORCID 0000-0003-4015-0284
Dong-A University · KR

Funding

Dong-A University Dong-A University
6 · The paper itself

Abstract

Six transmembrane protein of prostate 2 (STAMP2) is a critical modulator of inflammation and metabolism in adipose tissue. There are no data on the expression of STAMP2 in chronic kidney disease, which is an inflammatory disease related to metabolic disorders. This study aimed to investigate STAMP2 expression in the kidney and heart in 5/6 nephrectomy (Nx) rats, and the effect of omega-3 fatty acid (FA) on STAMP2 expression. Male Sprague Dawley rats were divided into three groups: sham control (0.9% saline), 5/6 Nx (0.9% saline), and 5/6 Nx treated with omega-3 FA (300 mg per kg per day by gastric gavage). The expression of STAMP2 in the kidney and heart were examined by western blotting. Serum creatinine levels were higher in 5/6 Nx rats than in controls. Compared with sham controls, the expression of IκB, NF-κB, NOX4, SREBP-1, and LXR were upregulated and STAMP2 and phosphorylated-AMPK expression were downregulated in the kidney and heart of 5/6 Nx rats. Omega-3 FA supplementation prevented these changes in biomarkers related to inflammation and metabolic lipid disorders. Omega 3-FA supplementation induced the upregulation of STAMP2 protein in 5/6 Nx rats, which was associated with an attenuation of inflammation- and metabolic disease-related markers.

Indexed as

AMP-Activated Protein Kinase KinasesAnimalsCreatinineDisease Models, AnimalFatty Acids, Omega-3I-kappa B ProteinsKidneyKidney Failure, ChronicLiver X ReceptorsMaleMembrane ProteinsMyocardiumNADPH Oxidase 4NephrectomyNF-kappa BProtein KinasesAMP-Activated Protein Kinase KinasesCreatinineFatty Acids, Omega-3I-kappa B ProteinsLiver X ReceptorsMembrane ProteinsNADPH Oxidase 4NF-kappa BNox4 protein, ratProtein KinasesSrebf1 protein, ratSterol Regulatory Element Binding Protein 1heartkidneyomega-3 fatty acidSTAMP2

Identifiers

PMID30360481
PMCPMC6267584
OpenAlexW2897571324

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.