ReviewInternational journal of molecular sciences2018
Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism.Frontiers in endocrinology · 2022Pooled it
- Immunohistochemical evaluation of androgen receptor expression in endometrial carcinoma and its clinicopathological significance.Diagnostic pathology · 2026Article
- Autophagy and Lysosomal Dysregulation in Endometriosis: Therapeutic Opportunities and Molecular Insights.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Multi-omics biomarkers in female fertility: from oocyte quality to endometrial receptivity and clinical translation.Biomarker research · 2026Review
- Unveiling the Role of Vitamin D/VDR in Promoting Endometrial Decidualization.International journal of endocrinology · 2026Article
- Molecular Impact of Metabolic and Endocrine Disturbance on Endometrial Function in Polycystic Ovary Syndrome.International journal of molecular sciences · 2025Review
- The ExPAND Study: A Prospective Association Study into Endometriosis-Associated Pain, Neurosteroid Synthesis, and TRPM3.Biomolecules · 2025Article
- Bioinformatics Analysis Reveals Novel Differentially Expressed Genes Between Ectopic and Eutopic Endometrium in Women with Endometriosis.Journal of obstetrics and gynaecology of India · 2023Article
- Androgen signalling in the ovaries and endometrium.Molecular human reproduction · 2023Review
- Effects of testosterone treatment on anal sphincter damage repair in ovariectomized rats.Turkish journal of medical sciences · 2023Article
- A mouse model mimicking gender-affirming treatment with pubertal suppression followed by testosterone in transmasculine youth.Human reproduction (Oxford, England) · 2023Article
- Genetically predicted serum testosterone and risk of gynecological disorders: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Uterine bleeding: how understanding endometrial physiology underpins menstrual health.Nature reviews. Endocrinology · 2022Review
- Endometrium as Control of Endometriosis in Experimental Research: Assessment of Sample Suitability.Diagnostics (Basel, Switzerland) · 2022Article
- A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization.Frontiers in endocrinology · 2022Article
- Site-Specific Regulation of Sulfatase and Aromatase Pathways for Estrogen Production in Endometriosis.Frontiers in molecular biosciences · 2022Article
- AG-205 Upregulates Enzymes Involved in Cholesterol Biosynthesis and Steroidogenesis in Human Endometrial Cells Independently of PGRMC1 and Related MAPR Proteins.Biomolecules · 2021Article
- The Interplay of Sex Steroids, the Immune Response, and the Intestinal Microbiota.Trends in microbiology · 2021Review
- An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process.Journal of exposure science & environmental epidemiology · 2021Review
- The impact of aging on innate and adaptive immunity in the human female genital tract.Aging cell · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Peripheral tissue metabolism of steroids (intracrinology) is now accepted as a key way in which tissues, such as the endometrium, can utilise inactive steroids present in the blood to respond to local physiological demands and 'fine-tune' the activation or inhibition of steroid hormone receptor-dependent processes. Expression of enzymes that play a critical role in the activation and inactivation of bioactive oestrogens (E1, E2) and androgens (A4, T, DHT), as well as expression of steroid hormone receptors, has been detected in endometrial tissues and cells recovered during the menstrual cycle. There is robust evidence that increased expression of aromatase is important for creating a local microenvironment that can support a pregnancy. Measurement of intra-tissue concentrations of steroids using liquid chromatography⁻tandem mass spectrometry has been important in advancing our understanding of a role for androgens in the endometrium, acting both as active ligands for the androgen receptor and as substrates for oestrogen biosynthesis. The emergence of intracrinology, associated with disordered expression of key enzymes such as aromatase, in the aetiology of common women's health disorders such as endometriosis and endometrial cancer has prompted renewed interest in the development of drugs targeting these pathways, opening up new opportunities for targeted therapies and precision medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.