ArticleThe Korean journal of internal medicine2019
The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis.
Article in The Korean journal of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Brain Metastases in Cervical Cancer: A Global Systematic Review and Meta-Analysis of Incidence and Clinicopathological Features.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Treatment of HER2-Positive Brain Metastasis from Cervical Cancer Using Multimodal Therapy Including Pyrotinib: A Case Report.International journal of women's health · 2026Article
- Risk and prognosis for brain metastasis in primary metastatic cervical cancer patients: A population-based study.Open medicine (Warsaw, Poland) · 2025Article
- Therapeutic Options for Brain Metastases in Gynecologic Cancers.Current treatment options in oncology · 2022Review
- A Research Study to Measure the Efficacy of Terminating Cervical Cancer via Customized Optimum Pathway.Journal of healthcare engineering · 2022Article
- Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis.Frontiers in cell and developmental biology · 2022Review
- The risk of distant metastases in patients with gynecologic cancers after surgery: a population-based study.Aging · 2021Article
- Review
- Effect of MiR-375 Regulates YAP1 on the Invasion, Apoptosis, and Epithelial-Mesenchymal Transition of Cervical Cancer HeLa Cells.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Patterns of metastases in cervical cancer: a population-based study.International journal of clinical and experimental pathology · 2020Article
- Multimodal Therapy is a Better Choice for Patients with Brain Metastasis from Cervical Cancer.Cancer management and research · 2020Article
- Article
- Clinical characteristics of CNS metastases from primary gynecologic cancers.Gynecologic oncology reports · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsThe occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in uterine cervical cancer remains scarce due to the rarity of BM in this type of cancer. The present study evaluated the clinical characteristics and prognostic factors influencing OS in patients with BM from uterine cervical cancer.
methodsA total of 19 BM patients of uterine cervical cancer were analyzed retrospectively from January 1995 to December 2016.
resultsThe median and mean OS of all patients was 9.6 and 15.4 months. Treatment (vs. palliative care, p < 0.001), fewer than three regimens of chemotherapy before BM (vs. ≥ 3, p < 0.013), and chemotherapy after BM (vs. absence, p < 0.001) significantly increased the OS time. The Karnofsky performance status ≥ 70 (vs. < 70, p = 0.213), single BM (vs. multiple BM, p = 0.157), and small cell carcinoma (vs. others, p = 0.351) had numerically higher OS than others. Dual therapy (vs. single therapy, p = 0.182; vs. no therapy, p = 0.076) were associated with a longer OS time, but the difference did not reach statistical significance. In addition, the graded prognostic assessment (GPA) appeared to be a better prognostic tool than the recursive partitioning analysis.
conclusionThe results of the present study suggest active multimodal treatment including neurosurgery, radiotherapy, and chemotherapy for BM of uterine cervical cancer with single BM, good performance status, histology of small cell carcinoma, and a better GPA.
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