Evidence map›Paper›PMID 30359906›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2018

Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors.

Artem A Gorodetskii, Timothy D Eubank, Benoit Driesschaert, Martin Poncelet, Emily Ellis, Valery V Khramtsov, Andrey A Bobko

Abstract read
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Artem A GorodetskiiIn Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA; Department of Biochemistry, West Virginia University, School of Medicine, Morgantown, WV 26506, USA; N.N. Voroztsov Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk 630090, Russia; Novosibirsk State University, Novosibirsk 630090, Russia.
Timothy D EubankIn Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA; Department of Microbiology, Immunology & Cell Biology, West Virginia University, School of Medicine, Morgantown, WV 26506, USA; West Virginia University Cancer Institute, Morgantown, WV 26506, USA.
Benoit DriesschaertIn Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA; Department of Pharmaceutical Sciences, West Virginia University, School of Pharmacy, Morgantown, WV 26506, USA; West Virginia University Cancer Institute, Morgantown, WV 26506, USA.
Martin PonceletIn Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA; Department of Biochemistry, West Virginia University, School of Medicine, Morgantown, WV 26506, USA.
Emily EllisDepartment of Microbiology, Immunology & Cell Biology, West Virginia University, School of Medicine, Morgantown, WV 26506, USA.
Valery V KhramtsovIn Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA; Department of Biochemistry, West Virginia University, School of Medicine, Morgantown, WV 26506, USA; West Virginia University Cancer Institute, Morgantown, WV 26506, USA. Electronic address: valery.khramtsov@hsc.wvu.edu.
Andrey A BobkoIn Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA; Department of Biochemistry, West Virginia University, School of Medicine, Morgantown, WV 26506, USA; West Virginia University Cancer Institute, Morgantown, WV 26506, USA. Electronic address: andrey.bobko@hsc.wvu.edu.
West Virginia University · USNovosibirsk Institute of Organic Chemistry · RU

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Dominique Bollino · 2018 to 2026
$22.4M
In vivo monitoring of tumor microenvironment regulation for macrophagesR01CA194013 · NCI · WEST VIRGINIA UNIVERSITY · PI Timothy D Eubank, Valery V Khramtsov · 2015 to 2026
$3.5M
Profiling chemical tumor microenvironment: Application for diagnostics & therapyR01CA192064 · NCI · WEST VIRGINIA UNIVERSITY · PI EUBANK, TIMOTHY D, KHRAMTSOV, VALERY V · 2015 to 2024
$3.4M
Biocompatible Magnetic Resonance Probes for in vivo Concurrent Profiling R00EB023990 · NIBIB · WEST VIRGINIA UNIVERSITY · PI DRIESSCHAERT, BENOIT · 2019 to 2021
$730k
Biocompatible Magnetic Resonance Probes for in vivo Concurrent Profiling of Interstitial Oxygenation, Acidosis and Inorganic Phosphate: Preclinical Application to CancerK99EB023990 · NIBIB · WEST VIRGINIA UNIVERSITY · PI DRIESSCHAERT, BENOIT · 2017 to 2018
$153k
NCI NIH HHS R01 CA192064NCI NIH HHS R01 CA194013NIBIB NIH HHS K99 EB023990NIBIB NIH HHS R00 EB023990NIGMS NIH HHS P20 GM121322NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Overhauser-enhanced Magnetic Resonance Imaging (OMRI) is a double resonance technique applied for oxygen imaging in aqueous samples and biological tissues. In this report, we present an improved OMRI approach of oxygen measurement using the single line "Finland" trityl spin probe. Compared to a traditional approach, we introduced an additional mechanism of leakage of spin polarization due to an interaction of a spin system with oxygen. The experimental comparison of the new approach with an oxygen-dependent leakage factor to a traditional approach performed in phantom samples in vitro, and mouse tumor model in vivo, shows improved accuracy of determination of oxygen and contrast agent concentrations.

Indexed as

AlgorithmsAnimalsContrast MediaElectron Spin Resonance SpectroscopyHumansMagnetic Resonance ImagingMiceMice, TransgenicNeoplasmsNeoplasms, ExperimentalOximetryOxygenPhantoms, ImagingProtonsContrast MediaOxygenProtonsLeakage of spin polarizationOverhauser-enhanced magnetic resonance imaging (OMRI)OximetryProton-electron double-resonance imaging (PEDRI)Trityl radicalTumor tissue oximetry

Identifiers

PMID30359906
PMCPMC6289650
OpenAlexW2895996507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.