ArticleNeurobiology of aging2019
Comparison of longitudinal Aβ in nondemented elderly and Down syndrome.
Abstract readComparative Study
In one paragraph
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Imaging and plasma biomarkers for pathological accumulation in Down syndrome.Brain : a journal of neurology · 2026Article
- Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Age and sex are associated with Alzheimer's disease neuropathology in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The striatum is an early, accurate indicator of amyloid burden using [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials.Brain communications · 2025Article
- Characterizing the emergence of amyloid and tau burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Alzheimer's disease associated with Down syndrome: a genetic form of dementia.The Lancet. Neurology · 2021Review
- Article
- Postmortem NeocorticalFrontiers in aging neuroscience · 2021Article
- Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer's Disease.Frontiers in aging neuroscience · 2021Review
- Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories.Neurobiology of aging · 2020Article
- Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer's disease.Acta neuropathologica · 2020Article
- Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.Acta neuropathologica · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Dana L TudorascuDepartment of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA.
Stewart J AndersonDepartment of Biostatistics, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA.
Davneet S MinhasDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Zheming YuDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Diane ComerDepartment of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Patrick LaoDepartment of Medical Physics, University of Wisconsin, Madison School of Medicine, Madison, WI, USA; Department of Waisman Center, University of Wisconsin, Madison School of Medicine, Madison, WI, USA.
Sigan HartleyDepartment of Waisman Center, University of Wisconsin, Madison School of Medicine, Madison, WI, USA; Departments of Human Development and Family Studies, University of Wisconsin, Madison School of Medicine, Madison, WI, USA.
Charles M LaymonDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biongeenering, University of Pittsburgh, Pittsburgh, PA, USA.
Beth E SnitzDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Brian J LoprestiDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sterling JohnsonDepartment of Medical Physics, University of Wisconsin, Madison School of Medicine, Madison, WI, USA; Department of Medicine and Geriatrics, University of Wisconsin, Madison School of Medicine, Madison, WI, USA.
Julie C PriceDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Massachusetts General Hospital, A. A. Martinos Center for Biomedical Imaging, Cambridge, MA, USA.
Chester A MathisDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Howard J AizensteinDepartment of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
William E KlunkDepartment of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Benjamin L HandenDepartment of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Brad T ChristianDepartment of Medical Physics, University of Wisconsin, Madison School of Medicine, Madison, WI, USA; Department of Waisman Center, University of Wisconsin, Madison School of Medicine, Madison, WI, USA.
Ann D CohenDepartment of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: cohenad@upmc.edu.
University of Pittsburgh · USUniversity of Wisconsin–Madison · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MProject 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUDORASCU, DANA L · 2020 to 2025
$103.7MVascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ann D. Cohen · 2005 to 2026
$56.5MTREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0MNiAD Supplement WashU Start UpU01AG051406 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONSTANTINO, JOHN N., HANDEN, BENJAMIN L · 2015 to 2019
$21.3MWisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, JEFFREY A · 2009 to 2018
$16.2MRoles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyRF1AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, VILLEMAGNE, VICTOR LUIS · 2014 to 2021
$9.0MNatural History of Amyloid Deposition in Adults with Down SyndromeR01AG031110 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L · 2009 to 2016
$5.2MAMYLOID PATHOLOGY AND COGNITION IN NORMAL ELDERLYR37AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLUNK, WILLIAM E · 2005 to 2014
$4.3MAlzheimer neuroimaging-biomarkers in pre-clinical cognitive decline from a population-based studyR01AG052521 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SNITZ, BETH · 2016 to 2020
$3.3MNIA NIH HHS P01 AG025204NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG031110NIA NIH HHS R01 AG052521NIA NIH HHS R37 AG025516NIA NIH HHS RF1 AG025516NIA NIH HHS U01 AG051406NIA NIH HHS U19 AG068054NIA NIH HHS U24 AG021886
Abstract
Down syndrome (DS) predisposes individuals to early Alzheimer's disease (AD). Using Pittsburgh Compound B ([
Indexed as
AdultAgedAged, 80 and overAmyloid beta-PeptidesAniline CompoundsCohort StudiesDown SyndromeFemaleFrontal LobeHeterozygoteHumansLongitudinal StudiesMaleMiddle AgedParietal LobeThiazoles2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsThiazolesAlzheimer's diseaseAmyloidDown syndrome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.