Evidence map›Paper›PMID 30359877›Full record

ArticleNeurobiology of aging2019

Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats.

V Alexandra Moser, Amy Christensen, Jiahui Liu, Amanda Zhou, Shunya Yagi, Christopher R Beam, Liisa Galea, Christian J Pike

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Testosterone, cognitive decline and dementia in ageing men.Reviews in endocrine & metabolic disorders · 2022
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Androgens and Adult Neurogenesis in the Hippocampus.Androgens: clinical research and therapeutics · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

V Alexandra MoserNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
Amy ChristensenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Jiahui LiuLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Amanda ZhouLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Shunya YagiDjavad Mowafaghian Centre for Brain Health, Department of Psychology, University of British Columbia, Vancouver BC, Canada.
Christopher R BeamDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Liisa GaleaDjavad Mowafaghian Centre for Brain Health, Department of Psychology, University of British Columbia, Vancouver BC, Canada.
Christian J PikeNeuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. Electronic address: cjpike@usc.edu.
University of Southern California · USUniversity of British Columbia · CA

Funding

RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
Sex differences in the relationship between APOE and AD: Role of sexual differentiationRF1AG058068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, LADU, MARY JO · 2017 to 2017
$3.8M
Amyloid and inflammation: modulation by apoE, gender, air pollution, and drugsRF1AG051521 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2015 to 2015
$3.0M
Interactions between Testosterone and Type 2 Diabetes in Alzheimer's Disease PathR01AG034103 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PIKE, CHRISTIAN J · 2011 to 2015
$1.6M
NIA NIH HHS R01 AG034103NIA NIH HHS RF1 AG051521NIA NIH HHS RF1 AG058068NIA NIH HHS T32 AG000037
6 · The paper itself

Abstract

Risk for Alzheimer's disease (AD) is affected by multiple factors, including aging, obesity, and low testosterone. We previously showed that obesity and low testosterone independently and interactively exacerbate AD-related outcomes in young adult rodents. The goals of the present study are two-fold: to examine whether the effects of an obesogenic diet differ with increasing age and to determine if testosterone treatment in middle-aged and aged animals mitigates negative effects of the diet. Male brown Norway rats were maintained on control or high-fat diets for 12 weeks beginning in young adulthood, middle age, or advanced age. Separate cohorts of middle-aged and aged animals were treated with testosterone during dietary manipulations. Endpoints included metabolic indices, inflammation, cognitive performance, and neural health outcomes. Aging was associated with poorer outcomes that were generally exacerbated by high-fat diet, especially at middle age. Testosterone treatment was largely without benefit, exerting only subtle effects on a select number of measures. Understanding how the deleterious effects of obesity are affected by advancing age and the ability of protective strategies such as testosterone to reduce these effects may provide significant insight into both the development and prevention of age-related cognitive decline and AD.

Indexed as

AgingAlzheimer DiseaseAnimalsCognitionDiet, High-FatInflammationMaleObesityRats, Inbred BNTestosteroneTestosteroneAgingDiet-induced obesityHigh-fat dietNeuroinflammationTestosterone

Identifiers

PMID30359877
PMCPMC6252085
OpenAlexW2893543473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.