Evidence map›Paper›PMID 30359872›Full record

ArticleThe International journal on drug policy2018

Individual, social, and structural factors affecting antiretroviral therapy adherence among HIV-positive people who inject drugs in Kazakhstan.

Alissa Davis, Tara McCrimmon, Anindita Dasgupta, Louisa Gilbert, Assel Terlikbayeva, Timothy Hunt, Sholpan Primbetova, Elwin Wu, Meruyert Darisheva, Nabila El-Bassel

Abstract read
In one paragraph

Article in The International journal on drug policy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Scaling Up HIV Self-Testing and Linkage to Care Among Women Who Exchange Sex and/or Use Drugs in Kazakhstan.AIDS education and prevention : official publication of the International Society for AIDS Education · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alissa DavisSocial Intervention Group, School of Social Work, Columbia University, 1255 Amsterdam Avenue, 8th Floor, New York, NY, 10027, United States. Electronic address: ad3324@columbia.edu.
Tara McCrimmonSocial Intervention Group, School of Social Work, Columbia University, 1255 Amsterdam Avenue, 8th Floor, New York, NY, 10027, United States.
Anindita DasguptaSocial Intervention Group, School of Social Work, Columbia University, 1255 Amsterdam Avenue, 8th Floor, New York, NY, 10027, United States.
Louisa GilbertSocial Intervention Group, School of Social Work, Columbia University, 1255 Amsterdam Avenue, 8th Floor, New York, NY, 10027, United States.
Assel TerlikbayevaColumbia University Global Health Research Center of Central Asia, 38B Shashkina Street, 3rd Floor, Almaty, 050040, Kazakhstan.
Timothy HuntColumbia University Global Health Research Center of Central Asia, 38B Shashkina Street, 3rd Floor, Almaty, 050040, Kazakhstan.
Sholpan PrimbetovaColumbia University Global Health Research Center of Central Asia, 38B Shashkina Street, 3rd Floor, Almaty, 050040, Kazakhstan.
Elwin WuSocial Intervention Group, School of Social Work, Columbia University, 1255 Amsterdam Avenue, 8th Floor, New York, NY, 10027, United States.
Meruyert DarishevaColumbia University Global Health Research Center of Central Asia, 38B Shashkina Street, 3rd Floor, Almaty, 050040, Kazakhstan.
Nabila El-BasselSocial Intervention Group, School of Social Work, Columbia University, 1255 Amsterdam Avenue, 8th Floor, New York, NY, 10027, United States.

Funding

The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Claude Ann Mellins · 2003 to 2026
$48.2M
INSPIRE : Interdisciplinary Social and Behavioral Science Prevention and Intervention REsearch in HIVT32MH019139 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Claude Ann Mellins, Jae M. Sevelius · 1989 to 2026
$10.8M
Training Program on HIV and Substance Use in the Criminal Justice SystemT32DA037801 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nabila El-Bassel, Lisa R Metsch · 2014 to 2026
$5.7M
Improving HIV Service Delivery for People who Inject Drugs in KazakhstanR01DA041063 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI EL-BASSEL, NABILA, GILBERT, LOUISA · 2015 to 2019
$4.7M
A couple-based antiretroviral therapy adherence intervention for people who inject drugs in KazakhstanK01DA044853 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DAVIS, ALISSA · 2018 to 2022
$903k
NIDA NIH HHS K01 DA044853NIDA NIH HHS R01 DA041063NIDA NIH HHS T32 DA037801NIMHD NIH HHS L60 MD010932NIMH NIH HHS P30 MH043520NIMH NIH HHS T32 MH019139
6 · The paper itself

Abstract

backgroundHIV-infected people who inject drugs (PWID) are particularly vulnerable to suboptimal ART adherence. The fastest-growing HIV epidemics globally are driven by injection drug use, but only a small percentage of HIV-positive PWID have achieved viral suppression. Virally suppressed individuals have better HIV-related health outcomes and effectively no risk of transmitting HIV to others. Hence, ART adherence is important for both HIV treatment and HIV prevention. There is a paucity of data on barriers and facilitators of ART adherence among PWID in low and middle income countries, which is problematic given the growing HIV epidemics among PWID in these countries.

methodsUsing the Theory of Triadic Influence, this paper examines individual, interpersonal, and structural barriers and facilitators of ART adherence among HIV-positive PWID in four cities in Kazakhstan. Eight focus groups were conducted (two in each city) with a total of 57 participants. Data were coded and analyzed by three researchers.

resultsWe found a number of barriers and facilitators to ART adherence among PWID at the individual, interpersonal, and structural levels. Individual barriers to ART adherence include misperceptions about ART, forgetfulness due to the effects of illicit drug use, and medication side effects. Interpersonal facilitators of ART adherence include social support and good relationships with healthcare providers. Structural barriers include poverty, legal challenges, disruptions in the ART supply, and stigma and discrimination.

conclusionThe paper highlights important factors related to ART adherence for HIV-positive PWID and identifies potential strategies for intervention efforts, including couple-based interventions, electronic reminders, linkage to drug treatment services, and patient navigation. Effectively enhancing adherence to ART among PWID will likely require multi-level approaches and strategies. Further research should be conducted on potential methods and interventions for improving ART adherence among this vulnerable population.

Indexed as

Acquired Immunodeficiency SyndromeAdultAnti-HIV AgentsAnti-Retroviral AgentsDrug UsersFemaleHIV InfectionsHumansKazakhstanMaleMedication AdherenceMiddle AgedQualitative ResearchSocial StigmaSubstance Abuse, IntravenousAnti-HIV AgentsAnti-Retroviral AgentsAdherenceAntiretroviral therapyHIVPeople who inject drugs

Identifiers

PMID30359872
PMCPMC6279490

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.