Evidence map›Paper›PMID 30359787›Full record

ArticleNuclear medicine and biology2018

Automated radiosynthesis of 5-[

Adam J Rosenberg, Michael L Nickels, Michael L Schulte, H Charles Manning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. l-[5-Acta pharmaceutica Sinica. B · 2025
    Article
  2. Review
  3. First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Adam J RosenbergVanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute for Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael L NickelsVanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute for Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael L SchulteVanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute for Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
H Charles ManningVanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute for Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA. Electronic address: henry.c.manning@vanderbilt.edu.
Vanderbilt University Medical Center · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
VU PREDICTU24CA220325 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOPETZ, SCOTT, MANNING, HENRY CHARLES · 2018 to 2022
$3.3M
Radiochemistry Equipment for Molecular Imaging Tracer ProductionS10OD023543 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2017 to 2017
$359k
Radiofluorination Equipment for PET Imaging ResearchS10OD019963 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2016 to 2016
$291k
NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA091842NCI NIH HHS U24 CA220325NIDDK NIH HHS P30 DK058404NIH HHS S10 OD019963NIH HHS S10 OD023543
6 · The paper itself

Abstract

introductionThe natural amino acid l-Glutamine (Gln) is essential for both cell growth and proliferation. In addition to glucose, cancer cells utilize Gln as a carbon source for ATP production, biosynthesis, and as a defense against reactive oxygen species. The utilization of [

methodsThe preparation of [

resultsAutomated production by this method reliably provides over 3.7 GBq (100 mCi) of [

conclusionsA fast, reliable and efficient automated radiosynthesis was developed using a commercially available module. Purifications used throughout allow for both a radiochemically and chemically pure final product solution of [

Indexed as

AutomationCarbon RadioisotopesChemistry Techniques, SyntheticGlutamineRadioactive TracersRadiochemistryCarbon-11Carbon RadioisotopesGlutamineRadioactive Tracers[(11)C]GlutamineAutomated radiosynthesisCarbon-11MetabolismPETRadiopharmaceuticals

Identifiers

PMID30359787
PMCPMC6298813
OpenAlexW2896892553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.