SynthesisChest2019
Change in FEV
Synthesis in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Predictors of asthma exacerbations in children with or without house dust mite allergy.International journal of occupational medicine and environmental health · 2026Observational
- Longitudinal FeNO monitoring in pediatric asthma: association of FeNO and its trajectory patterns with asthma control status.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Breathing Out the Truth: What Fractional Exhaled Nitric Oxide Really Tells Us About Pediatric Asthma.Diagnostics (Basel, Switzerland) · 2026Review
- Spirometry to manage asthma in children: study protocol for a randomised controlled trial (SPIROMAC).Trials · 2025Article
- Article
- Risk factor analysis and nomogram for predicting poor symptom control in smoking asthmatics.BMC pulmonary medicine · 2024Article
- Objective monitoring tools for improved management of childhood asthma.Respiratory research · 2024Review
- Impact of Lung Function on Asthma Exacerbation Rates in Children Treated with Dupilumab: The VOYAGE Study.Journal of asthma and allergy · 2024Article
- Therapeutic patient education: Impact on lung function in Moroccan adult asthma patients?Journal of education and health promotion · 2024Article
- A retrospective analysis of the clinical efficacy in patients treated withFrontiers in allergy · 2024Article
- Medication Adherence in Children with Asthma.Patient preference and adherence · 2024Review
- Prediction of Asthma Exacerbations in Children.Journal of personalized medicine · 2023Review
- Use of exhaled nitric oxide in the diagnosis and monitoring of childhood asthma: myth or maxim?Breathe (Sheffield, England) · 2023Review
- Article
- Routine FEVBreathe (Sheffield, England) · 2023Review
- Update on the Role of FeNO in Asthma Management.Diagnostics (Basel, Switzerland) · 2023Review
- Asthma medication adherence and exacerbations and lung function in children managed in Leicester primary care.NPJ primary care respiratory medicine · 2023Review
- Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Can the Chinese study on the normal range of FeNO in children evaluate standardized asthma treatment efficacy in 6- to 12-year-old children?Frontiers in pediatrics · 2023Article
- Associations and dose-response relationships between different kinds of urine polycyclic aromatic hydrocarbons metabolites and adult lung functions.Environmental science and pollution research international · 2022Article
Corrections and comments
- Commented on by
- Commented on byResponse.2019
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRepeated measurements of spirometry and fractional exhaled nitric oxide (Feno) are recommended as part of the management of childhood asthma, but the evidence base for such recommendations is small. We tested the hypothesis that reducing spirometric indices or increasing Feno will predict poor future asthma outcomes.
methodsA one-stage individual patient data meta-analysis used data from seven randomized controlled trials in which Feno was used to guide asthma treatment; spirometric indices were also measured. Change in %FEV
resultsData were available from 1,112 children (mean age, 12.6 years; mean %FEV
conclusionsRepeated measurements of %FEV
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.