Evidence map›Paper›PMID 30359609›Full record

ReviewNeuron2018

Working Memory 2.0.

Earl K Miller, Mikael Lundqvist, André M Bastos

Abstract readReview
In one paragraph

Review in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 421 papers.

0numbers the graph read from it
0cells of the map it votes in
421citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

421 citing papers in PubMed.

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  19. Similar Response Dynamics Represent Opposite Behaviors and Rewards in the Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  20. Article

361 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Earl K MillerThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: ekmiller@mit.edu.
Mikael LundqvistThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
André M BastosThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Funding

Cortical Circuits for Attention and DecisionsR37MH087027 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MILLER, EARL K · 2010 to 2019
$4.7M
Capacity Limitations in the CortexR01MH091174 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MILLER, EARL K · 2011 to 2015
$2.0M
Testing the Mechanisms, Layers, and Frequencies of Prediction Encoding and its ViolationK99MH116100 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BASTOS, ANDRE MORAES · 2018 to 2020
$328k
NIMH NIH HHS K99 MH116100NIMH NIH HHS R01 MH091174NIMH NIH HHS R37 MH087027
6 · The paper itself

Abstract

Working memory is the fundamental function by which we break free from reflexive input-output reactions to gain control over our own thoughts. It has two types of mechanisms: online maintenance of information and its volitional or executive control. Classic models proposed persistent spiking for maintenance but have not explicitly addressed executive control. We review recent theoretical and empirical studies that suggest updates and additions to the classic model. Synaptic weight changes between sparse bursts of spiking strengthen working memory maintenance. Executive control acts via interplay between network oscillations in gamma (30-100 Hz) in superficial cortical layers (layers 2 and 3) and alpha and beta (10-30 Hz) in deep cortical layers (layers 5 and 6). Deep-layer alpha and beta are associated with top-down information and inhibition. It regulates the flow of bottom-up sensory information associated with superficial layer gamma. We propose that interactions between different rhythms in distinct cortical layers underlie working memory maintenance and its volitional control.

Indexed as

Models, NeurologicalAnimalsBrainHumansMemory, Short-Termbottom-upcognitioncortexoscillationsprefrontal cortexsynchronytop-downworking memory

Identifiers

PMID30359609
PMCPMC8112390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.