Evidence map›Paper›PMID 30359544›Full record

Trial reportCancer biology & therapy2019

Dynamic changes of different phenotypic and genetic circulating tumor cells as a biomarker for evaluating the prognosis of RCC.

Zhen-Long Wang, Peng Zhang, He-Cheng Li, Xiao-Jie Yang, Ya-Ping Zhang, Zhao-Lun Li, Li Xue, Yu-Quan Xue, Hong-Liang Li, Qi Chen and 1 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer biology & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhen-Long Wanga Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Peng Zhanga Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
He-Cheng Lia Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Xiao-Jie Yanga Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Ya-Ping Zhanga Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Zhao-Lun Lia Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Li Xuea Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Yu-Quan Xuea Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Hong-Liang Lia Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Qi Chena Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.
Tie Chonga Department of Urology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirculating tumor cells (CTCs) and relevant autophagy Beclin-1 genes expression are critical biomarkers for tumorigenesis and tumor progress. Here we investigated the relationship of dynamic changes of CTCs and Beclin-1 expression of CTCs with renal cell carcinoma (RCC) prognosis. MATERIALS AND

methodsA total of 69 patients with RCC were enrolled and divided into two groups based on the postoperative status of distant metastasis, including metastasis-free group (n = 58) and metastatic group (n = 11). Demographic characteristics of each patient were recorded in detail. All 69 enrolled patients had received multiple CTC tests and peripheral blood samples were obtained at three different time points (1 day before operation, 6 months and 12 months after operation). Peripheral blood samples were drawn before each time point and CTCs were separated by using Can Patrol CTC enrichment technique. CTCs were divided into epithelial, mesenchymal and mixed phenotype based on different surface biomarkers. RNA in situ hybridization assay was used to detect the expression of Beclin1 gene.

resultsThe percentages of epithelial, mesenchymal and mixed CTCs were 11.64%, 28.04% and 60.32%, respectively. There were no significant differences of initial CTCs counts between metastasis-free group (8.43 ± 5.15) and metastatic group (7.71 ± 3.82) (P > 0.05). As for metastatic group, the number of mixed CTCs at 12 months postoperatively was significantly higher than that of mixed CTCs preoperatively and 6 months postoperatively (P < 0.05). In the metastatic group, the number of Beclin1 positive CTCs was significantly higher than that of Beclin1 negative CTCs preoperatively (P < 0.05), moreover, there were several significantly changes of Beclin1 positive CTCs with different types and at different time points.

conclusionThe recurrence or metastasis of RCC was uncorrelated with initial CTCs counts, but probably related with the variation trend of CTCs, especially mesenchymal CTCs and Beclin1 positive CTCs.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, PapillaryCarcinoma, Renal CellDNA, NeoplasmEpithelial-Mesenchymal TransitionFemaleFollow-Up StudiesHumansKidney NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalNeoplastic Cells, CirculatingBiomarkers, TumorDNA, NeoplasmBeclin-1CTCsKidney cancerPrognosisRCC

Identifiers

PMID30359544
PMCPMC6422478

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.