Evidence map›Paper›PMID 30359430›Full record

ArticlePloS one2018

Contraceptive use following unintended pregnancy among Ugandan women living with HIV.

Jana Jarolimova, Jerome Kabakyenga, Kara Bennett, Winnie Muyindike, Annet Kembabazi, Jeffrey N Martin, Peter W Hunt, Yap Boum, Jessica E Haberer, David R Bangsberg and 2 more

Abstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jana JarolimovaDepartment of Medicine, Massachusetts General Hospital, Boston, MA, United States.ORCID 0000-0002-6787-3012
Jerome KabakyengaMbarara University of Science and Technology, Mbarara, Uganda.
Kara BennettBennett Statistical Consulting, Ballston Lake, NY, United States.
Winnie MuyindikeMbarara University of Science and Technology, Mbarara, Uganda.
Annet KembabaziMbarara University of Science and Technology, Mbarara, Uganda.
Jeffrey N MartinUniversity of California at San Francisco, San Francisco, CA, United States.
Peter W HuntUniversity of California at San Francisco, San Francisco, CA, United States.
Yap BoumEpicentre, Médicins sans Frontières (MSF), Yaounde, Cameroon.
Jessica E HabererCenter for Global Health and Department of Medicine, Massachusetts General Hospital; Harvard Medical School, Boston, MA, United States.
David R BangsbergOregon Health and Science University-Portland State University School of Public Health, Portland, OR, United States.
Angela KaidaSimon Fraser University, Faculty of Health Sciences, Burnaby, British Columbia, Canada.
Lynn T MatthewsCenter for Global Health and Division of Infectious Disease, Massachusetts General Hospital, Boston, MA, United States.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
TB PREVENTION AND HIV IN THE HOMELESS--AN INTERVENTIONR01MH054907 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 1995 to 2014
$20.7M
West Coast AIDS and Cancer Specimen Resource (ACSR)U01CA066529 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCGRATH, MICHAEL SHANNON · 1994 to 2012
$16.1M
Periconception HIV risk reduction for HIV-discordant couples in UgandaK23MH095655 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2011 to 2015
$854k
Fertility desire and pregnancy in a cohort of discordant Ugandan couples on ARTR21HD069194 · NICHD · SIMON FRASER UNIVERSITY · PI KAIDA, ANGELA KANANA · 2011 to 2012
$303k
NCI NIH HHS U01 CA066529NIAID NIH HHS P30 AI027763NICHD NIH HHS R21 HD069194NIMH NIH HHS K23 MH095655NIMH NIH HHS R01 MH054907
6 · The paper itself

Abstract

backgroundPreventing unintended pregnancy is critical for women living with HIV (WLWH) to safely achieve their reproductive goals. Family planning services should support WLWH at risk of repeat unintended pregnancies. We examined the relationship between unintended pregnancy and subsequent contraception use among WLWH in Uganda. STUDY

designThis was a retrospective analysis of data from a longitudinal cohort of individuals initiating antiretroviral therapy (ART), restricted to women with pregnancy (confirmed via urine β-hcg testing) between 2011-2013. The exposure of interest was intended vs unintended pregnancy, and the outcome was self-report of modern contraceptive use (hormonal methods, intrauterine device, sterilization, and/or consistent condom use) at 12 (range 6-18) months post-partum. A log-binomial model was used to estimate relative risks of modern contraceptive use post-partum based on intent of the index pregnancy, adjusted for age, socioeconomic status, education, relationship and HIV status of pregnancy partner, contraceptive use prior to pregnancy, years since HIV diagnosis, ART regimen, and CD4 cell count.

resultsAmong 455 women, 110 women reported 110 incident pregnancies with report on intent. Women had a baseline median age of 29 years, baseline CD4 count 403 cells/mm3, and were living with HIV for 3.8 years. Fifty pregnancies (45%) were reported as unintended and 60 (55%) as intended. Postpartum, 64% of women with unintended and 51% with intended pregnancy reported modern contraception (p = 0.24). In adjusted models, there was no association between pregnancy intent and post-partum contraception. However, contraceptive use prior to the referent pregnancy was positively associated with post-partum contraceptive use (aRR 1.97 (95% CI 1.12-3.48, p = 0.02), while higher baseline CD4 cell count was associated with lower post-partum contraceptive use (aRR 0.95, 95% CI 0.90-0.99, p = 0.02).

conclusionsAlmost half of incident pregnancies among WLWH in this cohort were unintended. Experiencing an unintended pregnancy was not associated with post-partum contraceptive use. Creative strategies to support contraceptive uptake for birth spacing and prevention of unintended pregnancies in the post-partum period are needed.

Indexed as

Pregnancy, UnplannedAdultContraception BehaviorFamily Planning ServicesFemaleHIV InfectionsHumansLongitudinal StudiesPostpartum PeriodPregnancyRetrospective StudiesUganda

Identifiers

PMID30359430
PMCPMC6201927

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.