Evidence map›Paper›PMID 30359307›Full record

ArticleStem cell research & therapy2018

Human decidua basalis mesenchymal stem/stromal cells protect endothelial cell functions from oxidative stress induced by hydrogen peroxide and monocytes.

M A Alshabibi, T Khatlani, F M Abomaray, A S AlAskar, B Kalionis, S A Messaoudi, R Khanabdali, A O Alawad, M H Abumaree

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Perinatal derivatives: How to best characterize their multimodal functionsFrontiers in bioengineering and biotechnology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

M A AlshabibiNational Center for Stem Cell Technology, Life Sciences and Environment Research Institute, King Abdulaziz City for Science and Technology, P.O Box 6086, Riyadh, 11442, Kingdom of Saudi Arabia.
T KhatlaniStem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Mail Code 1515, P.O. Box 22490, Riyadh, 11426, Saudi Arabia.
F M AbomarayDivision of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 141 86, Stockholm, Sweden.
A S AlAskarStem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Mail Code 1515, P.O. Box 22490, Riyadh, 11426, Saudi Arabia.
B KalionisDepartment of Maternal-Fetal Medicine Pregnancy Research Centre, University of Melbourne, Melbourne, Australia.
S A MessaoudiDepartment of Forensic Biology, College of Forensic Sciences, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia.
R KhanabdaliDepartment of Maternal-Fetal Medicine Pregnancy Research Centre, University of Melbourne, Melbourne, Australia.
A O AlawadNational Center for Stem Cell Technology, Life Sciences and Environment Research Institute, King Abdulaziz City for Science and Technology, P.O Box 6086, Riyadh, 11442, Kingdom of Saudi Arabia.
M H AbumareeStem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Mail Code 1515, P.O. Box 22490, Riyadh, 11426, Saudi Arabia. mohamedabumaree@hotmail.com.ORCID 0000-0002-8869-7476
King Abdulaziz City for Science and Technology · SAKing Saud bin Abdulaziz University for Health Sciences · SARoyal Women's Hospital · AUKarolinska Institutet · SEKing Abdulaziz Medical City · SANaif Arab University for Security Sciences · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman decidua basalis mesenchymal stem/multipotent stromal cells (DBMSCs) inhibit endothelial cell activation by inflammation induced by monocytes. This property makes them a promising candidate for cell-based therapy to treat inflammatory diseases, such as atherosclerosis. This study was performed to examine the ability of DBMSCs to protect endothelial cell functions from the damaging effects resulting from exposure to oxidatively stress environment induced by H

methodsDBMSCs were co-cultured with endothelial cells isolated from human umbilical cord veins in the presence of H

resultsDBMSCs reversed the effect of H

conclusionsWe conclude that DBMSCs have potential for therapeutic application in inflammatory diseases, such as atherosclerosis by protecting endothelial cells from oxidative stress damage. However, more studies are needed to elucidate this further.

Indexed as

AdultAntigens, CDBiomarkersCell AdhesionCell Adhesion MoleculesCell ProliferationCoculture TechniquesCulture Media, ConditionedDeciduaFemaleGene ExpressionGlutathione ReductaseHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideMesenchymal Stem CellsAntigens, CDBiomarkersCell Adhesion MoleculesCulture Media, ConditionedGlutathione ReductaseHydrogen PeroxideThioredoxin-Disulfide ReductaseAdhesionDecidua basalis mesenchymal stem cellsEndothelial cellsH2O2MigrationMonocytesPlacentaProliferation

Identifiers

PMID30359307
PMCPMC6202803
OpenAlexW2898513561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.