Evidence map›Paper›PMID 30359203›Full record

ArticleGut microbes2019

Opportunistic bacteria confer the ability to ferment prebiotic starch in the adult cystic fibrosis gut.

Yanan Wang, Lex E X Leong, Rebecca L Keating, Tokuwa Kanno, Guy C J Abell, Fredrick M Mobegi, Jocelyn M Choo, Steve L Wesselingh, A James Mason, Lucy D Burr and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  8. Effect of a fructooligosaccharides fraction fromBioscience of microbiota, food and health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yanan Wanga Infection and Immunity Theme , South Australia Health and Medical Research Institute , Adelaide , Australia.
Lex E X Leonga Infection and Immunity Theme , South Australia Health and Medical Research Institute , Adelaide , Australia.ORCID 0000-0002-5073-2272
Rebecca L Keatingc Department of Respiratory Medicine , Mater Health Services , South Brisbane , Australia.
Tokuwa Kannod King's College London , Institute of Pharmaceutical Science , London , UK.
Guy C J Abella Infection and Immunity Theme , South Australia Health and Medical Research Institute , Adelaide , Australia.
Fredrick M Mobegia Infection and Immunity Theme , South Australia Health and Medical Research Institute , Adelaide , Australia.ORCID 0000-0003-0554-9919
Jocelyn M Chooa Infection and Immunity Theme , South Australia Health and Medical Research Institute , Adelaide , Australia.
Steve L Wesselingha Infection and Immunity Theme , South Australia Health and Medical Research Institute , Adelaide , Australia.
A James Masond King's College London , Institute of Pharmaceutical Science , London , UK.ORCID 0000-0003-0411-602X
Lucy D Burrc Department of Respiratory Medicine , Mater Health Services , South Brisbane , Australia.ORCID 0000-0003-4010-3787
Geraint B Rogersa Infection and Immunity Theme , South Australia Health and Medical Research Institute , Adelaide , Australia.
Flinders University · AUKing's College London · GBMater Health Services · AUSouth Australian Health and Medical Research Institute · AU

Funding

British Heart FoundationWellcome Trust
6 · The paper itself

Abstract

Chronic disruption of the intestinal microbiota in adult cystic fibrosis (CF) patients is associated with local and systemic inflammation, and has been linked to the risk of serious comorbidities. Supplementation with high amylose maize starch (HAMS) might provide clinical benefit by promoting commensal bacteria and the biosynthesis of immunomodulatory metabolites. However, whether the disrupted CF gut microbiota has the capacity to utilise these substrates is not known. We combined metagenomic sequencing,

Indexed as

FermentationPrebioticsAdultAmyloseBacteriaBiodiversityCystic FibrosisFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeHumansMaleMetabolomeMetagenomeMiddle AgedAmyloseFatty Acids, VolatilePrebioticsRNA, Ribosomal, 16SStarchCystic fibrosisfermentationresistant starchshort chain fatty acids

Identifiers

PMID30359203
PMCPMC6546330
OpenAlexW2898601962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.