ArticleCirculation research2018
Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models.
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Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 293 papers, 1 of them a synthesis that pooled it.
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293citing papers in PubMed, 1 pooled it
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Who cites it
293 citing papers in PubMed, 1 synthesis or guideline pooled it, 427 citations in OpenAlex.
- Next-Generation and Single-Cell Sequencing Approaches to Study Atherosclerosis and Vascular Inflammation Pathophysiology: A Systematic Review.Frontiers in cardiovascular medicine · 2022Pooled it
- Transcriptomic, Specific Marker, and Pathway Analysis of Smooth Muscle Cell Foam Cells Relative to Macrophage Foam Cells in Human Atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Macrophage CCRL2 promotes NLRP3 inflammasome activation to exacerbate atherosclerosis.Cellular & molecular immunology · 2026Article
- Intermittent exposure to high-altitude work: nocturnal hypoxemia sea-level anthropometric and biochemical markers.Sleep & breathing = Schlaf & Atmung · 2026Article
- Foamy microglia link oxylipins to disease progression in multiple sclerosis.Nature neuroscience · 2026Article
- Macrophage EHD1 Promotes Inflammation and Stabilizes Sortilin to Accelerate Atherosclerosis.Circulation research · 2026Article
- Heritable single-cell gene expression states shape functional variability in innate immune responses.bioRxiv : the preprint server for biology · 2026Article
- CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Diabetes-induced TREM2-endothelial cell signaling impairs ischemic vascular repair.Science translational medicine · 2026Article
- From Storage to Signaling: Lipid Droplet Lipolysis in Cholesterol Mobilization and Foam Cell Remodeling.Current atherosclerosis reports · 2026Review
- Lipid-associated macrophages and metabolic inflammatory diseases.Cell insight · 2026Review
- Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines.Journal of the American Heart Association · 2026Article
- ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis.The Journal of clinical investigation · 2026Article
- Single-cell spatial transcriptomics reveals clonal smooth muscle cell heterogeneity and programs associated with atherosclerotic plaque calcification.Clinical and experimental medicine · 2026Article
- Slc7a11-Mediated Cystine/Glutamate Antiport Reprograms Macrophage Polarization and Ameliorates Atherosclerosis.MedComm · 2026Article
- Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Integrating Untargeted Metabolomics and Transcriptomics in Mice with Pulmonary Tuberculosis to Reveal Changes in Linoleic Acid and Its Metabolism in Lung Monocyte-Derived Macrophages.Pathogens (Basel, Switzerland) · 2026Article
- Increased atherosclerosis and expression of inflammarafts in macrophage foam cells in AIBP-deficient mice.Scientific reports · 2026Article
- A Road Map to Understanding Cardiovascular Disease in Diabetes: From the AHA Strategically Focused Research Network in Cardiometabolic Health and Type 2 Diabetes.Circulation research · 2026Review
- Research progress on macrophage regulation of atherosclerosis.Frontiers in cardiovascular medicine · 2026Review
233 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 6 institutions in 3 countries.
Kyeongdae KimFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Dahee ShimFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Jun Seong LeeLaboratory of Cellular Physiology and Immunology (J.S.L., T.J.Y., C.C.), Institut de Recherches Cliniques de Montréal, Canada.
Konstantin ZaitsevDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (K.Z., J.W.W., K.-W.K., G.J.R., M.N.A.).
Jesse W WilliamsDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (K.Z., J.W.W., K.-W.K., G.J.R., M.N.A.).
Ki-Wook KimDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (K.Z., J.W.W., K.-W.K., G.J.R., M.N.A.).
Man-Young JangFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Hyung Seok JangFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Tae Jin YunLaboratory of Cellular Physiology and Immunology (J.S.L., T.J.Y., C.C.), Institut de Recherches Cliniques de Montréal, Canada.
Seung Hyun LeeFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Won Kee YoonBiomedical Mouse Resource Center, Korean Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Republic of Korea (W.K.Y.).
Annik PratLaboratory of Biochemical Neuroendocrinology (A.P., N.G.S.), Institut de Recherches Cliniques de Montréal, Canada.
Nabil G SeidahLaboratory of Biochemical Neuroendocrinology (A.P., N.G.S.), Institut de Recherches Cliniques de Montréal, Canada.
Jungsoon ChoiDepartment of Mathematics (J.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Seung-Pyo LeeCardiovascular Center and Department of Internal Medicine, Seoul National University Hospital, Republic of Korea (S.-P.L.).
Sang-Ho YoonFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Jin Wu NamFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Je Kyung SeongLaboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, College of Veterinary Medicine, Korea Mouse Phenotyping Center, Seoul National University, Republic of Korea (J.K.S.).
Goo Taeg OhDepartment of Life Sciences, Immune and Vascular Cell Network Research Center, National Creative Initiatives, Ewha Womans University, Seoul, Republic of Korea (G.T.O.).
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (K.Z., J.W.W., K.-W.K., G.J.R., M.N.A.).
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (K.Z., J.W.W., K.-W.K., G.J.R., M.N.A.).
Cheolho CheongLaboratory of Cellular Physiology and Immunology (J.S.L., T.J.Y., C.C.), Institut de Recherches Cliniques de Montréal, Canada.
Jae-Hoon ChoiFrom the Department of Life Sciences (K.K., D.S., M.-Y.J., H.S.J., S.H.L., S.-H.Y., J.W.N., J.-H.C.), College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Hanyang University · KRMontreal Clinical Research Institute · CAWashington University in St. Louis · USEwha Womans University · KRKorea Research Institute of Bioscience and Biotechnology · KRSeoul National University · KR
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWOMEN'S HEALTH AGENDAU01AI025903 · NIAID · WASHINGTON UNIVERSITY · PI CLIFFORD, DAVID B · 1987 to 2006
$12.5MDIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3MINTEGRATING CELL & LIPOPROTEIN TRAFFICKING WITH VASCULAR BIOLOGY IN HUMAN IBDDP1DK109668 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2015 to 2019
$3.8MATHEROSCLEROTIC LESION INITIATION BY RESIDENT AORTIC MACROPHAGE PROLIFERATION AND LIPID UPTAKEK99HL138163 · NHLBI · WASHINGTON UNIVERSITY · PI WILLIAMS, JESSE WARREN · 2018 to 2018
$125kCIHR 148363CIHR FRN 125933NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NHLBI NIH HHS K99 HL138163NIAID NIH HHS R37 AI049653NIAID NIH HHS U01 AI025903NIDDK NIH HHS DP1 DK109668
Abstract
rationaleMonocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of lipid-laden foamy macrophages in the subintimal space during atherosclerosis.
objectiveWe sought to examine the transcriptomic profiles of foamy and nonfoamy macrophages isolated from atherosclerotic intima. METHODS AND
resultsSingle-cell RNA sequencing analysis of CD45
conclusionsRNA sequencing analysis of intimal macrophages from atherosclerotic aorta revealed that lipid-loaded plaque macrophages are not likely the plaque macrophages that drive lesional inflammation.
Indexed as
TranscriptomeAnimalsAortaCells, CulturedHumansMacrophagesMaleMiceMice, Inbred C57BLPlaque, Atheroscleroticatherosclerosisflow cytometryfoam cellsmacrophagesmiceRNA-seq
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