ArticleBehavioral neuroscience2018
Psychosocial stress reactivity is associated with decreased whole-brain network efficiency and increased amygdala centrality.
Article in Behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- History of childhood trauma enhances the detrimental effects of recent stressors on brain structure and function in major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Amygdala reactivity to social stress in young adults: A scoping review of neuroimaging studies.Neurobiology of stress · 2026Review
- Violence exposure moderates stress-elicited neurobehavioral function in young people.Emotion (Washington, D.C.) · 2026Article
- Neural Mechanisms of Shooting Preparation Under High-Risk and High-Precision Tasks: A Multiscale EEG Study.Brain and behavior · 2026Article
- Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.Behavioural neurology · 2026Article
- The role of amygdala reactivity in affective fluctuations across social contexts.Scientific reports · 2025Article
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Adverse childhood experiences, brain efficiency, and the development of pain symptoms in youth.European journal of pain (London, England) · 2025Article
- Shedding Light on the Aftermath: Childhood Maltreatment's Role in Modifying the Association Between Recent Life Stress and Resting-State Network Connectivity.Behavioral sciences (Basel, Switzerland) · 2024Article
- Impact of prenatal marijuana exposure on adolescent brain structural and functional connectivity and behavioural outcomes.Brain communications · 2024Article
- Well-being is associated with cortical thickness network topology of human brain.Behavioral and brain functions : BBF · 2023Article
- Stress-induced Changes in Autonomic Reactivity Vary with Adolescent Violence Exposure and Resting-state Functional Connectivity.Neuroscience · 2023Article
- Stress-Induced Changes in Effective Connectivity During Regulation of the Emotional Response to Threat.Brain connectivity · 2022Article
- The Stressed Brain: Neural Underpinnings of Social Stress Processing in Humans.Current topics in behavioral neurosciences · 2022Review
- Sex-related Differences in Stress Reactivity and Cingulum White Matter.Neuroscience · 2021Article
- Violence exposure, affective style, and stress-induced changes in resting state functional connectivity.Cognitive, affective & behavioral neuroscience · 2020Article
- The dynamic properties of a brain network during working memory based on the algorithm of cross-frequency coupling.Cognitive neurodynamics · 2020Article
- Repeatability of Neural and Autonomic Responses to Acute Psychosocial Stress.Frontiers in neuroscience · 2020Article
- Ventromedial prefrontal cortex connectivity during and after psychological stress in women.Psychophysiology · 2019Article
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Authors and funding
9 authors.
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Abstract
Cognitive and emotional functions are supported by the coordinated activity of a distributed network of brain regions. This coordinated activity may be disrupted by psychosocial stress, resulting in the dysfunction of cognitive and emotional processes. Graph theory is a mathematical approach to assess coordinated brain activity that can estimate the efficiency of information flow and determine the centrality of brain regions within a larger distributed neural network. However, limited research has applied graph-theory techniques to the study of stress. Advancing our understanding of the impact stress has on global brain networks may provide new insight into factors that influence individual differences in stress susceptibility. Therefore, the present study examined the brain connectivity of participants that completed the Montreal Imaging Stress Task (Goodman et al., 2016; Wheelock et al., 2016). Salivary cortisol, heart rate, skin conductance response, and self-reported stress served as indices of stress, and trait anxiety served as an index of participant's disposition toward negative affectivity. Psychosocial stress was associated with a decrease in the efficiency of the flow of information within the brain. Further, the centrality of brain regions that mediate emotion regulation processes (i.e., hippocampus, ventral prefrontal cortex, and cingulate cortex) decreased during stress exposure. Interestingly, individual differences in cortisol reactivity were negatively correlated with the efficiency of information flow within this network, whereas cortisol reactivity was positively correlated with the centrality of the amygdala within the network. These findings suggest that stress reduces the efficiency of information transfer and leaves the function of brain regions that regulate the stress response vulnerable to disruption. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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