ArticleJournal of medicinal chemistry2018
Preclinical Evaluation of the First Adenosine A
Open access · greenAbstract read
In one paragraph
Article in Journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Development and Preclinical Evaluation of PET Radiotracers Targeting Adenosine AACS medicinal chemistry letters · 2025Article
- Species dependence of APurinergic signalling · 2023Review
- The adenosine hypothesis of schizophrenia into its third decade: From neurochemical imbalance to early life etiological risks.Frontiers in cellular neuroscience · 2023Review
- Structure-activity features of purines and their receptors: implications in cell physiopathology.Molecular biomedicine · 2022Review
- Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2022Article
- Discovery of Highly Potent Adenosine AACS chemical neuroscience · 2021Article
- Molecular probes for the human adenosine receptors.Purinergic signalling · 2021Review
- Dual Inhibition of Ornithine Decarboxylase and AFrontiers in oncology · 2021Article
- Quantitative Rodent Brain Receptor Imaging.Molecular imaging and biology · 2020Review
- Chemical Probes for the Adenosine Receptors.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Non-Nucleoside Agonists of the Adenosine Receptors: An Overview.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Design and in Vivo Characterization of AJournal of medicinal chemistry · 2019Article
- Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development.Frontiers in cellular neuroscience · 2019Review
- Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications.Molecular imagingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Min GuoLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.ORCID 0000-0003-4632-7116
Zhan-Guo GaoLaboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , Maryland 20892-0810 , United States.
Ryan TylerLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Tyler StoddenLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Yang LiLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Joseph RamseyLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Wen-Jing ZhaoLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Gene-Jack WangLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Corinde E WiersLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Joanna S FowlerLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
Kenner C RiceDrug Design and Synthesis Section , National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Rockville , Maryland 20892 , United States.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , Maryland 20892-0810 , United States.ORCID 0000-0001-8104-1493
Sung Won KimLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.ORCID 0000-0002-4647-4899
Nora D VolkowLaboratory of Neuroimaging , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda , Maryland 20892-1013 , United States.
National Institutes of Health · USNational Institute on Drug Abuse · US
Funding
Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1MMedicinal Chemistry of Drugs Acting on Central and Peripheral Opioid ReceptorsZIADA000527 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI RICE, KENNER · 2009 to 2025
$23.2MDevelopment Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4MNeurobiology of Substance Abuse & Addiction - Preclinical StudiesZIAAA000551 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2013
$8.2MMedicinal Chemistry in the Study of Alcohol AbuseZIADA000531 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI RICE, KENNER · 2009 to 2016
$1.1MDrugs that Act at Adenosine ReceptorsZ01DK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$854kIntramural NIH HHS Z01 DK031117Intramural NIH HHS Z99 AA999999Intramural NIH HHS Z99 DA999999Intramural NIH HHS ZIA AA000551Intramural NIH HHS ZIA DA000531Intramural NIH HHS ZIA DK031117NIDDK NIH HHS ZIA DK031117
Abstract
Central adenosine A
Indexed as
Positron-Emission TomographyAdenosine A1 Receptor AgonistsBlood-Brain BarrierHEK293 CellsHumansLigandsReceptor, Adenosine A1Structure-Activity RelationshipAdenosine A1 Receptor AgonistsLigandsReceptor, Adenosine A1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.