Evidence map›Paper›PMID 30358848›Full record

ReviewInflammatory bowel diseases2019

The Role of Cannabis in the Management of Inflammatory Bowel Disease: A Review of Clinical, Scientific, and Regulatory Information.

Arun Swaminath, Eric P Berlin, Adam Cheifetz, Ed Hoffenberg, Jami Kinnucan, Laura Wingate, Sarah Buchanan, Nada Zmeter, David T Rubin

Abstract readReview
In one paragraph

Review in Inflammatory bowel diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Use of Complementary and Alternative Therapies in People with Inflammatory Bowel Disease.International journal of environmental research and public health · 2024
    Article
  5. Article
  6. Article
  7. A Survey of Cannabis Use among Patients with Inflammatory Bowel Disease (IBD).International journal of environmental research and public health · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arun SwaminathDepartment of Medicine, Northwell Health, Great Neck, New York, USA.
Eric P BerlinJones Day Law Firm, Cleveland, Ohio, USA.
Adam CheifetzDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Ed HoffenbergCenter for Pediatric Inflammatory Bowel Disease, Children's Hospital Colorado, Denver, Colorado, USA.
Jami KinnucanDepartment of Medicine, University of Michigan Medicine, Ann Arbor, Michigan, USA.
Laura WingateCrohn's and Colitis Foundation; New York, New York, USA.
Sarah BuchananCrohn's and Colitis Foundation; New York, NY, USA.
Nada ZmeterUniversity of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, USA.
David T RubinUniversity of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, USA.

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
NIDDK NIH HHS P30 DK042086
6 · The paper itself

Abstract

There is significant interest among patients and providers in using cannabis (marijuana) and its derivatives to treat a number of chronic illnesses, including inflammatory bowel disease. Despite the Schedule I classification of cannabis by the federal government, state governments have sought ways to make cannabis available for specific medical conditions, and some states have legalized cannabis outright. This white paper summarizes the preclinical data, clinical data, safety data, and the regulatory landscape as they apply to medical cannabis use in inflammatory bowel disease. Animal models of cannabinoid chemistry and physiology give evidence of anti-inflammatory, antidiarrheal, and nociceptive-limiting properties. Human studies have found benefit in controlling symptoms and improving quality of life, but no studies have established true disease modification given the absent improvement in biomarker profiles or endoscopic healing. Finally, this review describes the legal, regulatory, and practical hurdles to studying the risks and benefits of medical cannabis in the United States. 10.1093/ibd/izy319_video1 izy319.video1 5852852028001.

Indexed as

Government RegulationDisease ManagementHumansInflammatory Bowel DiseasesMedical MarijuanaPrognosisMedical MarijuanacannabisCrohn’s diseaseinflammatory bowel diseasemarijuanaTHCulcerative colitis

Identifiers

PMID30358848
PMCPMC7534377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.