SynthesisThe journal of trauma and acute care surgery2019
The incidence and associations of acute kidney injury in trauma patients admitted to critical care: A systematic review and meta-analysis.
Synthesis in The journal of trauma and acute care surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Biomarkers for assessing acute kidney injury for people who are being considered for admission to critical care: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2022Pooled it
- The Spatially Resolved Kidney Transcriptome Signatures in Rat Models of Trauma-Induced Acute Kidney Injury.Kidney360 · 2026Article
- The global epidemiology of acute kidney injury: challenges and opportunities.Nature reviews. Nephrology · 2026Review
- Bimodal distribution of trauma-related acute kidney injury (TrAKI): A clinical review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Review
- Kidneys on the Frontline: Nephrologists Tackling the Wilds of Acute Kidney Injury in Trauma Patients-From Pathophysiology to Early Biomarkers.Diagnostics (Basel, Switzerland) · 2025Review
- Risk factors and prognosis of post-surgical acute kidney injury in elderly patients based on the MIMIC-IV database.European journal of medical research · 2025Review
- How Does Contrast Administration Influence Creatinine Dynamics in Trauma Patients With Acute Kidney Injury?Cureus · 2025Article
- Article
- Risk of acute kidney injury following repeated contrast exposure in trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Risk factors for and outcomes of acute kidney injury in ward-based hospital trauma admissions: A retrospective cohort analysis.PloS one · 2025Article
- Positive Effects of Argon Inhalation After Traumatic Brain Injury in Rats.International journal of molecular sciences · 2024Article
- Renal angioembolization vs. surgery for high-grade renal trauma: a nationwide comparative analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Traumatic rhabdomyolysis: rare but morbid, potentially lethal, and inconsistently monitored.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Review
- Article
- Selection of appropriate reference creatinine estimate for acute kidney injury diagnosis in patients with severe trauma.Acute and critical care · 2023Article
- Minor injury turns into major problem in severe acute kidney injury: a propensity matched analysis.Trauma surgery & acute care open · 2023Article
- The Predictive Role of Systemic Inflammatory Markers in the Development of Acute Kidney Failure and Mortality in Patients with Abdominal Trauma.Journal of personalized medicine · 2022Article
- Specificity of severe AKI aetiology and care in the elderly. The IRACIBLE prospective cohort study.Journal of nephrology · 2022Article
- Incidence of Acute Kidney Injury in Polytrauma Patients and Predictive Performance of TIMP2 × IGFBP7 Biomarkers for Early Identification of Acute Kidney Injury.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs more patients are surviving the initial effects of traumatic injury clinicians are faced with managing the systemic complications of severe tissue injury. Of these, acute kidney injury (AKI) may be a sentinel complication contributing to adverse outcomes.
objectiveTo establish the incidence of AKI in patients admitted to critical care after major trauma, to explore any risk factors and to evaluate the association of AKI with outcomes. DATA SOURCES: Systematic search of MEDLINE, Excerpta Medica database and Cochrane library from January 2004 to April 2018. STUDY SELECTION: Studies of adult major trauma patients admitted to critical care that applied consensus AKI criteria (risk injury failure loss end stage [RIFLE], AKI network, or kidney disease improving global outcomes) and reported clinical outcomes were assessed (PROSPERO Registration: CRD42017056781). Of the 35 full-text articles selected from the screening, 17 (48.6%) studies were included. DATA EXTRACTION AND SYNTHESIS: We followed the PRISMA guidelines and study quality was assessed using the Newcastle-Ottawa score. The pooled incidence of AKI and relative risk of death were estimated using random-effects models. MAIN OUTCOMES AND MEASURES: Incidence of AKI was the primary outcome. The secondary outcome was study-defined mortality.
resultsWe included 17 articles describing AKI outcomes in 24,267 trauma patients. The pooled incidence of AKI was 20.4% (95% confidence interval [CI], 16.5-24.9). Twelve studies reported the breakdown of stages of AKI with 55.7% of patients classified as RIFLE-R or stage 1, 30.3% as RIFLE-I or stage 2, and 14.0% as RIFLE-F or stage 3. The pooled relative risk of death with AKI compared was 3.6 (95% CI, 2.4-5.3). In addition, there was a concordant increase in odds of death among six studies that adjusted for multiple variables (adjusted odds ratio, 2.7; 95% CI, 1.9-3.8; p = <0.01).
conclusionAcute kidney injury is common after major trauma and associated with increased mortality. Future research is warranted to reduce the potential for harm associated with this subtype of AKI. LEVEL OF EVIDENCE: Systematic review and meta-analysis, level III.
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