Evidence map›Paper›PMID 30358440›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Cyclodextrins reduce the ability of Pseudomonas aeruginosa outer-membrane vesicles to reduce CFTR Cl

Roxanna Barnaby, Katja Koeppen, Bruce A Stanton

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Outer membrane vesicles secreted byInfection and immunity · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Mesenchymal stromal cell extracellular vesicles reduceAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  7. Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reducebioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity ofProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Roxanna BarnabyDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Katja KoeppenDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Bruce A StantonDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Dartmouth College · US

Funding

Role of Virulence Factors in Pseudomonas-Host InteractionsR01HL074175 · NHLBI · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 2003 to 2018
$5.0M
NHLBI NIH HHS R01 HL074175
6 · The paper itself

Abstract

Pseudomonas aeruginosa secretes outer-membrane vesicles (OMVs) that fuse with cholesterol-rich lipid rafts in the apical membrane of airway epithelial cells and decrease wt-CFTR Cl

Indexed as

Cell-Derived MicroparticlesCystic FibrosisMembrane Microdomains2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinsBiofilmsBronchiCell LineChloridesCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsHumansPseudomonas aeruginosa2-Hydroxypropyl-beta-cyclodextrinbeta-CyclodextrinsCFTR protein, humanChloridesCystic Fibrosis Transmembrane Conductance Regulatormethyl-beta-cyclodextrinCFTRcyclodextrincystic fibrosislumacaftor

Identifiers

PMID30358440
PMCPMC6383504
OpenAlexW2898128667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.