ArticleMicrobiologyOpen2019
Impact of high-grain diet feeding on mucosa-associated bacterial community and gene expression of tight junction proteins in the small intestine of goats.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 23 citations in OpenAlex.
- The Effects of Breeding Methods on Cecal Microflora and Production Traits of Yimeng Black Goats.Animals : an open access journal from MDPI · 2026Article
- Understanding the differences in rumen bacteria and their impact on dairy cows' production performance: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Effects of different fiber levels of energy feeds on rumen fermentation and the microbial community structure of grazing sheep.BMC microbiology · 2025Article
- Impact of mixed silages of licorice aerial parts and whole plant corn on nutrient digestibility, rumen fermentation, and gastrointestinal microbiota in Simmental cattle.Frontiers in veterinary science · 2025Article
- Sea Buckthorn Polysaccharide Ameliorates Colitis.Nutrients · 2024Article
- Ruminal microbiota and muscle metabolome characteristics of Tibetan plateau yaks fed different dietary protein levels.Frontiers in microbiology · 2024Article
- Effect ofSaudi journal of biological sciences · 2023Article
- High-grain diet feeding alters ileal microbiota and disrupts bile acid metabolism in lactating dairy cows.Journal of animal science · 2023Article
- Shifts and importance of viable bacteria in treatment of DSS-induced ulcerative colitis mice with FMT.Frontiers in cellular and infection microbiology · 2023Article
- Dietary spirulina supplementation modifies rumen development, fermentation and bacteria composition in Hu sheep when consuming high-fat dietary.Frontiers in veterinary science · 2023Article
- Dietary Supplementation of Fruit fromAnimals : an open access journal from MDPI · 2022Article
- Characteristics of ruminal microbiota and metabolome in Holstein cows differing in milk protein concentrations.Journal of animal science · 2022Article
- Effect ofFrontiers in microbiology · 2022Article
- Relationships among Indicators of Metabolism, Mammary Health and the Microbiomes of Periparturient Holstein Cows.Animals : an open access journal from MDPI · 2021Article
- Oral administration of Moringa oleifera leaf powder relieves oxidative stress, modulates mucosal immune response and cecal microbiota after exposure to heat stress in New Zealand White rabbits.Journal of animal science and biotechnology · 2021Article
- Comparison of the fermentation and bacterial community in the colon of Hu sheep fed a low-grain, non-pelleted, or pelleted high-grain diet.Applied microbiology and biotechnology · 2021Article
- Mucosal Microbiota and Metabolome in the Ileum of Hu Sheep Offered a Low-Grain, Pelleted or Non-pelleted High-Grain Diet.Frontiers in microbiology · 2021Article
- Effects of supplemental feeding on the fecal bacterial communities of Rocky Mountain elk in the Greater Yellowstone Ecosystem.PloS one · 2021Article
- Diet with a High Proportion of Rice Alters Profiles and Potential Function of Digesta-Associated Microbiota in the Ileum of Goats.Animals : an open access journal from MDPI · 2020Article
- Bighorn sheep gut microbiomes associate with genetic and spatial structure across a metapopulation.Scientific reports · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate the impact of a high-grain (HG) diet on the microbial fermentation, the composition of the mucosa-associated bacterial microbiota, and the gene expression of tight junction proteins in the small intestine of goats. In the present study, we randomly assigned 10 male goats to either a hay diet (n = 5) or a HG diet (56.5% grain; n = 5) and then examined changes in the bacterial community using Illumina MiSeq sequencing and the expression of tight junction proteins using qRT-PCR in the mucosa of the small intestine. The results showed that HG diet decreased the luminal pH (p = 0.005) and increased the lipopolysaccharide content (p < 0.001) in the digesta of the ileum, and it increased the concentration of total volatile fatty acids in the digesta of the jejunum (p = 0.015) and ileum (p = 0.007) compared with the hay diet. MiSeq sequencing results indicated that the HG diet increased (FDR = 0.007-0.028) the percentage of the genera Stenotrophomonas, Moraxella, Lactobacillus, and Prevotella in jejunal mucosa but decreased (FDR = 0.016) the abundance of Christensenellaceae R7 group in the ileal mucosa compared with the hay diet. Furthermore, the HG diet caused downregulation of the mRNA expression of claudin-4, occludin, and ZO-1 in jejunal and ileal mucosa (p < 0.05). Collectively, our data suggested that the HG diet induced changes in the relative abundance of some mucosa-associated bacteria, in addition to downregulation of the mRNA expression of tight junction proteins in the small intestine. These findings provide new insights into the adaptation response of the small intestine to HG feeding in ruminants.
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