ArticleObesity (Silver Spring, Md.)2018
Weight Cycling Increases Longevity Compared with Sustained Obesity in Mice.
Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Experimental Models of Weight Cycling: A Narrative Review of Protocol Design and Metabolic Outcomes.Journal of obesity · 2026Review
- Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake.GeroScience · 2024Article
- Article
- The Impact of Yoyo Dieting and Resistant Starch on Weight Loss and Gut Microbiome in C57Bl/6 Mice.Nutrients · 2024Article
- Impact of sustained calorie restriction and weight cycling on body composition in high-fat diet-fed male and female C57BL/6J mice.Obesity (Silver Spring, Md.) · 2024Article
- Does diet influence aging? Evidence from animal studies.Journal of internal medicine · 2024Review
- Associations between adverse childhood experiences and history of weight cycling.Obesity science & practice · 2024Article
- How is Big Data reshaping preclinical aging research?Lab animal · 2023Review
- Obesity and lifespan, a complex tango.Science translational medicine · 2023Review
- Weight cycling based on altered immune microenvironment as a result of metaflammation.Nutrition & metabolism · 2023Review
- Dietary Walnuts Preserve Aspects of Health Span and Alter the Hippocampal Lipidome in Aged High-Fat Diet-Fed Mice.International journal of molecular sciences · 2023Article
- Long Term Weight Cycling Affects Fecal Microbiota of Mice.Molecular nutrition & food research · 2022Article
- Risk of Type 2 Diabetes Among Individuals with Excess Weight: Weight Trajectory Effects.Current diabetes reports · 2022Review
- Diet composition influences the metabolic benefits of short cycles of very low caloric intake.Nature communications · 2021Article
- Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Increased frequency of intentional weight loss associated with reduced mortality: a prospective cohort analysis.BMC medicine · 2020Article
- Weight cycling is associated with adverse cardiometabolic markers in a cross-sectional representative US sample.Journal of epidemiology and community health · 2020Article
- Unexpected clues emerge about why diets fail.Nature medicine · 2019Article
- Effects of multiple cycles of weight loss and regain on the body weight regulatory system in rats.American journal of physiology. Endocrinology and metabolism · 2019Article
- Kynurenic acid as the neglected ingredient of commercial baby formulas.Scientific reports · 2019Article
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8 authors.
Funding
Abstract
objectiveDespite the known health benefits of weight loss among persons with obesity, observational studies have reported that cycles of weight loss and regain, or weight cycling, are associated with increased mortality. To study whether weight loss must be sustained to achieve health and longevity benefits, we performed a randomized controlled feeding study of weight cycling in mice.
methodsIn early adult life, obese mice were randomized to ad libitum feeding to sustain obesity, calorie restriction to achieve a "normal" or intermediate body weight, or weight cycling (repeated episodes of calorie restriction and ad libitum refeeding). Body weight, body composition, and food intake were followed longitudinally until death. A subsample of mice was collected from each group for determination of adipose cell size, serum analytes, and gene expression.
resultsWeight loss significantly reduced adipose mass and adipocyte size in both sexes, whereas weight cycling animals regained body fat and cell size during refeeding. Sustained weight loss resulted in a dose-dependent decrease in mortality compared with ad libitum feeding.
conclusionsWeight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.