ArticleObesity (Silver Spring, Md.)2018
BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization.
Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk.European heart journal · 2026Article
- Deviation From Genetically Predicted BMI and All-Cause Mortality: A Cohort Study in the UK Biobank.Obesity (Silver Spring, Md.) · 2026Article
- Nonparametric Bayesian Adjustment of Unmeasured Confounders in Cox Proportional Hazards Models.Statistics in medicine · 2026Article
- Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk.Nature medicine · 2025Article
- Chronic pain and mortality risk among middle-age and older Japanese: the Shika town cohort study.Pain reports · 2025Article
- Is the relationship between chronic pain and mortality causal? A propensity score analysis.Pain · 2025Article
- Causal inference in health and disease: a review of the principles and applications of Mendelian randomization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Review
- Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2024Article
- Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited.International journal of epidemiology · 2024Article
- Response to "Importance of method assumptions".Obesity (Silver Spring, Md.) · 2024Article
- Body mass index and all-cause mortality in HUNT and UK biobank studies: revised non-linear Mendelian randomisation analyses.BMJ open · 2024Article
- Independent relevance of adiposity measures to coronary heart disease risk among 0.5 million adults in UK Biobank.International journal of epidemiology · 2023Article
- Challenges in undertaking nonlinear Mendelian randomization.Obesity (Silver Spring, Md.) · 2023Article
- Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality.Journal of the American Heart Association · 2023Article
- Surrogate Adiposity Markers and Mortality.JAMA network open · 2023Article
- Leveraging family data to design Mendelian randomization that is provably robust to population stratification.Genome research · 2023Article
- The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study.European journal of epidemiology · 2023Article
- Comparison of intergenerational instrumental variable analyses of body mass index and mortality in UK Biobank.International journal of epidemiology · 2023Article
- Metabolic profiling of MRI-measured liver fat in the UK Biobank.Obesity (Silver Spring, Md.) · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
objectiveThe aim of this study was to obtain estimates of the causal relationship between BMI and mortality.
methodsMendelian randomization (MR) with BMI-associated genotypic variation was used to test the causal effect of BMI on all-cause and cause-specific mortality in UK Biobank participants of White British ancestry.
resultsMR analyses supported a causal association between higher BMI and greater risk of all-cause mortality (hazard ratio [HR] per 1 kg/m
conclusionsResults support a causal role of higher BMI in increasing the risk of all-cause mortality and mortality from several specific causes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.