ArticleChemMedChem2019
An Investigation into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics.
Article in ChemMedChem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Quinuclidin-3-one-based quaternary ammonium compounds as potent antibacterials againstBiomolecules & biomedicine · 2026Article
- Topology-Aware Generation and Activity-Based Filtering: A Computational-Experimental Framework for Data-Scarce Quaternary Ammonium Compound Discovery.Journal of chemical information and modeling · 2026Article
- Structure-Function Insights into Quinuclidine-3-One BisQACs: Synthesis, Modulation of Bacterial Resistance, Structure-Activity Relationship, and Biological Profiling.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Designing Antibacterial-Based Quaternary Ammonium Coatings (Surfaces) or Films for Biomedical Applications: Recent Advances.International journal of molecular sciences · 2024Review
- Naturally derived 3-aminoquinuclidine salts as new promising therapeutic agents.Scientific reports · 2024Article
- Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds.International journal of molecular sciences · 2024Review
- Further Study of the Polar Group's Influence on the Antibacterial Activity of the 3-Substituted Quinuclidine Salts with Long Alkyl Chains.Antibiotics (Basel, Switzerland) · 2023Article
- Synthesis and Biological Evaluation of 3-Amidoquinuclidine Quaternary Ammonium Compounds as New Soft Antibacterial Agents.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- New Membrane Active Antibacterial and Antiviral Amphiphiles Derived from Heterocyclic Backbone of Pyridinium-4-Aldoxime.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance.ACS infectious diseases · 2022Article
- An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation.ChemMedChem · 2021Article
- Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials.International journal of molecular sciences · 2021Review
- Trivalent sulfonium compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles.Bioorganic & medicinal chemistry letters · 2021Article
- Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures.ChemMedChem · 2021Article
- Advancements in the Development of Non-Nitrogen-Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance.ChemMedChem · 2020Review
- Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics.ChemMedChem · 2020Article
- Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids.ACS medicinal chemistry letters · 2020Article
- More QACs, more questions: Recent advances in structure activity relationships and hurdles in understanding resistance mechanisms.Tetrahedron letters · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Twenty-one mono- and biscationic quaternary ammonium amphiphiles (monoQACs and bisQACs) were rapidly prepared in order to investigate the effects of rigidity of a diamine core structure on antiseptic activity. As anticipated, the bioactivity against a panel of six bacteria including methicillin-resistant Staphylococcus aureus (MRSA) strains was strong for bisQAC structures, and is clearly correlated with the length of non-polar side chains. Modest advantages were noted for amide-containing side chains, as compared with straight-chained alkyl substituents. Surprisingly, antiseptics with more rigidly disposed side chains, such as those in DABCO-12,12, showed the highest level of antimicrobial activity, with single-digit MIC values or better against the entire bacterial panel, including sub-micromolar activity against an MRSA strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.