Evidence map›Paper›PMID 30358081›Full record

ArticleMolecular oncology2019

BCG-induced cytokine release in bladder cancer cells is regulated by Ca

Cristián Ibarra, Marie Karlsson, Simone Codeluppi, Manuel Varas-Godoy, Songbai Zhang, Lauri Louhivuori, Sara Mangsbo, Arad Hosseini, Navid Soltani, Rahim Kaba and 7 more

Open access · goldAbstract read
In one paragraph

Article in Molecular oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Identification of hub genes and pathways in bladder cancer using bioinformatics analysis.American journal of clinical and experimental urology · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. BCG: a vaccine with multiple faces.Human vaccines & immunotherapeutics · 2020
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Cristián IbarraDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Marie KarlssonDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Simone CodeluppiDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Manuel Varas-GodoyDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Songbai ZhangDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Lauri LouhivuoriDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Sara MangsboDepartment of Pharmaceutical Biosciences, Science for Life Laboratory, Uppsala University, Sweden.
Arad HosseiniDepartment of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden.
Navid SoltaniDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Rahim KabaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
T Kalle LundgrenDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Abolfazl HosseiniDepartment of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden.
Nobuyuki TanakaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Mototsugu OyaDepartment of Urology, Keio University School of Medicine, Tokyo, Japan.
Peter WiklundDepartment of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden.
Ayako MiyakawaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Per UhlénDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SEKeio University · JPScience for Life Laboratory · SE

Funding

Åke Wiberg's FoundationFredrik and Ingrid Thuring's FoundationHillevi Fries' FoundationKnut and Alice Wallenberg FoundationLinnaeus Center in Developmental Biology for Regenerative MedicineMagnus Bergvall's FoundationSigrid Jusélius FoundationSwedish Cancer Society CAN 2013-802Swedish Cancer Society CAN 2016-801Swedish Research Council 2009-3364Swedish Research Council 2013-3189Swedish Research Council 2017-00815The Karolinska Institutet's KID doctoral programThe Olle Engkvist FoundationThe Swedish Society for Medical ResearchThe Swedish Strategic Foundation
6 · The paper itself

Abstract

Bacillus Calmette-Guérin (BCG) is widely used in the clinic to effectively treat superficial urinary bladder cancer. However, a significant proportion of patients who fail to respond to BCG risk cystectomy or death. Though more than 3 million cancer treatments with BCG occur annually, surprisingly little is known about the initial signaling cascades activated by BCG. Here, we report that BCG induces a rapid intracellular Ca

Indexed as

Calcium SignalingCalciumCell Line, TumorCytokinesCytosolHumansInterleukin-8Mycobacterium bovisNF-kappa BToll-Like Receptor 4Urinary Bladder NeoplasmsCalciumCXCL8 protein, humanCytokinesInterleukin-8NF-kappa BTLR4 protein, humanToll-Like Receptor 4BCGcalcium signalingTLR4urinary bladder cancer

Identifiers

PMID30358081
PMCPMC6360358
OpenAlexW2898150411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.