Evidence map›Paper›PMID 30358001›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

Ultrashort echo time imaging for quantification of hepatic iron overload: Comparison of acquisition and fitting methods via simulations, phantoms, and in vivo data.

Aaryani Tipirneni-Sajja, Ralf B Loeffler, Axel J Krafft, Andrea N Sajewski, Robert J Ogg, Jane S Hankins, Claudia M Hillenbrand

Abstract readComparative Study
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Impact of particle size onMagnetic resonance in medicine · 2025
    Article
  4. Review
  5. Review
  6. Free-breathing MRI techniques for fat and RMagma (New York, N.Y.) · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aaryani Tipirneni-SajjaDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ralf B LoefflerDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Axel J KrafftDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Andrea N SajewskiDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Robert J OggDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jane S HankinsDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Claudia M HillenbrandDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Funding

PROFESSIONAL ONCOLOGY EDUCATION PROGRAMR25CA023944 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE A. GRONEMEYER · 1986 to 2026
$8.3M
Massive Iron Deposit Assessment (MIDAS)R01DK088988 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HANKINS, JANE SILVA, HILLENBRAND, CLAUDIA M · 2010 to 2013
$1.5M
NCI NIH HHS R25 CA023944NIDDK NIH HHS R01 DK088988
6 · The paper itself

Abstract

backgroundCurrent R2*-MRI techniques for measuring hepatic iron content (HIC) use various acquisition types and fitting models. PURPOSE: To evaluate the accuracy and precision of R2*-HIC acquisition and fitting methods. STUDY TYPE: Signal simulations, phantom study, and prospective in vivo cohort. POPULATION: In all, 132 patients (58/74 male/female, mean age 17.7 years). FIELD STRENGTH/SEQUENCE: 2D-multiecho gradient-echo (GRE) and ultrashort echo time (UTE) acquisitions at 1.5T. ASSESSMENT: Synthetic MR signals were created to mimic published GRE and UTE methods, using different R2* values (25-2000 s STATISTICAL TESTS: R2* accuracy was determined from the relative error and by linear regression analysis. Precision was evaluated using coefficient of variation (CoV) analysis.

resultsIn simulations, all models had high R2* accuracy (error <5%) and precision (CoV <10%) for all SNRs, shorter ΔTE (≤0.5 msec), and longer TE DATA

conclusionUTE with TE LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1475-1488.

Indexed as

AdolescentCohort StudiesFemaleHumansImage Interpretation, Computer-AssistedIronIron OverloadLiverMagnetic Resonance ImagingMalePhantoms, ImagingProspective StudiesReproducibility of ResultsSignal-To-Noise RatioIronhepatic iron overloadR2* quantificationsignal modelsultrashort echo time

Identifiers

PMID30358001
PMCPMC6768432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.