ArticleMagnetic resonance in medicine2019
Perfusion of the placenta assessed using arterial spin labeling and ferumoxytol dynamic contrast enhanced magnetic resonance imaging in the rhesus macaque.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- In Vivo Assessment of Placental Structure and Perfusion in Late-Gestation Pregnancies and Their Association With Fetal Growth.NMR in biomedicine · 2026Article
- BRIDGING COTYLEDON PATHOLOGY AND PERFUSION IN HEALTHY PRIMATE PREGNANCY.bioRxiv : the preprint server for biology · 2026Article
- Comparison of Laser Doppler Flowmetry With Contrast-Enhanced Ultrasound to Approximate Placental Microvascular Blood Flow in the African Green Monkey (Chlorocebus aethiops sabaeus).Journal of medical primatology · 2026Article
- Cotyledon-Specific Flow Evaluation of Rhesus Macaque Placental Injury Using Ferumoxytol Dynamic Contrast-Enhanced MRI.Journal of magnetic resonance imaging : JMRI · 2024Article
- Velocity-selective arterial spin labeling perfusion measurements in 2nd trimester human placenta with varying BMI.Placenta · 2024Article
- B-Flow/Spatiotemporal Image Correlation M-Mode and Contrast-Enhanced/Microbubble Ultrasonography Quantification of Spiral Artery Distensibility and Placental Intervillous Perfusion in the First Trimester in a Primate Model of Impaired Spiral Artery Remodeling.Ultrasound in medicine & biology · 2023Article
- The human placenta project: Funded studies, imaging technologies, and future directions.Placenta · 2023Review
- Ferumoxytol dynamic contrast enhanced magnetic resonance imaging identifies altered placental cotyledon perfusion in rhesus macaques†.Biology of reproduction · 2022Article
- Standard diffusion-weighted, diffusion kurtosis and intravoxel incoherent motion MR imaging of the whole placenta: a pilot study of volumetric analysis.Annals of translational medicine · 2022Article
- Nonhuman Primates in Translational Research.Annual review of animal biosciences · 2022Review
- The application ofJournal of developmental origins of health and disease · 2021Review
- The effects of maternal position, in late gestation pregnancy, on placental blood flow and oxygenation: an MRI study.The Journal of physiology · 2021Article
- Impact of ferumoxytol magnetic resonance imaging on the rhesus macaque maternal-fetal interface†.Biology of reproduction · 2020Article
- Perfusion and apparent oxygenation in the human placenta (PERFOX).Magnetic resonance in medicine · 2020Article
- Evaluation of a motion-robust 2D chemical shift-encoded technique for R2* and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques.Journal of magnetic resonance imaging : JMRI · 2020Article
- Using Macaques to Address Critical Questions in Zika Virus Research.Annual review of virology · 2019Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the correspondence between arterial spin labeling (ASL) flow-sensitive alternating inversion recovery (FAIR) and ferumoxytol DCE MRI for the assessment of placental intervillous perfusion.
methodsTen pregnant macaques in late second trimester were imaged at 3 T using a 2D ASL FAIR, with and without outer-volume saturation pulses used to control the bolus width, and a 3D ferumoxytol DCE-MRI acquisition. The ASL tagged/control pairs were averaged, subtracted, and normalized to create perfusion ratio maps. Contrast arrival time and uptake slope were estimated by fitting the DCE data to a sigmoid function. Macaques (N = 4) received interleukin-1β to induce inflammation and disrupt perfusion.
resultsThe FAIR tag modification with outer-volume saturation reduced the median ASL ratio percentage compared with conventional FAIR (0.64% ± 1.42% versus 0.71% ± 2.00%; P < .05). Extended ferumoxytol arrival times (34 ± 25 seconds) were observed across the placenta. No significant DCE signal change was measured in fetal tissue (
conclusionThe ASL-FAIR and ferumoxytol DCE-MRI methods are feasible to detect early blood delivery to the macaque placenta. Outer volume saturation reduced the high macrovascular ASL signal. Interleukin-1β exposure did not alter placental intervillous perfusion. An endogenous-labeling perfusion technique is limited due to extended transit times for flow within the placenta beyond the immediate vicinity of the maternal spiral arteries.
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