ArticleJournal of child psychology and psychiatry, and allied disciplines2019
Pubertal recalibration of cortisol reactivity following early life stress: a cross-sectional analysis.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early-life adversity.Journal of child psychology and psychiatry, and allied disciplines · 2021Trial
- Targeting the Proximal Mechanisms of Stress Adaptation in Early Adolescence to Prevent Mental Health Problems in Youth in Poverty.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Associations between Early Psychosocial Deprivation, Cognitive and Psychiatric Morbidity, and Risk-taking Behavior in Adolescence.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Let's Grow: Toward Culturally Sensitive Pubertal Research Practices with Migrant Adolescents.Journal of immigrant and minority health · 2026Article
- Early Childhood Emotional, Relational, and Stress-Related Outcomes Following Infant Cardiac Surgery.Developmental psychobiology · 2026Article
- The adrenal is doing what it's supposed to do, you just don't understand it.Neurobiology of stress · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Methodological trends in biological assessment of children's daily stress: A scoping review.PloS one · 2026Article
- Evaluating the Effectiveness of a School-Based Mental Health Training Programme: The Transformative, Resilient, Youth-Led (TRY) Gym.Healthcare (Basel, Switzerland) · 2025Article
- Hypothalamic-Pituitary-Adrenal Axis Recalibration During Puberty Among Maltreated Youth: The Role of Caregiver Depression.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- Developmental Differences in a Hippocampal-Cingulate Pathway Involved in Learned Safety Following Interpersonal Trauma Exposure.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Revisiting adolescence as a sensitive period for sociocultural processing.Neuroscience and biobehavioral reviews · 2024Review
- Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences.Frontiers in neuroendocrinology · 2024Review
- The Association Between Adverse Childhood Experiences and Preterm Delivery: A Latent Class Approach.Journal of women's health (2002) · 2024Article
- Cortisol's diurnal rhythm indexes the neurobiological impact of child adversity in adolescence.Biological psychology · 2024Article
- Assessing the stability of psychobiological stress reactivity during adolescence: mixed-effect modelling of cortisol responses to laboratory stressors.HRB open research · 2024Article
- Validation of the Chinese version of the adverse life experiences scale.Frontiers in pediatrics · 2024Article
- The Development of Stress Reactivity and Regulation in Children and Adolescents.Current neuropharmacology · 2024Review
- Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity.Development and psychopathology · 2023Article
- Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.The American psychologist · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChildren adopted from orphanages or other such institutions tend to display blunted reactivity to stressors - even years after arriving in their generally supportive and highly resourced postadoption homes. Puberty, a proposed sensitive period for environmental influences on stress-mediating systems, may provide an opportunity for postinstitutionalized children to recalibrate stress response systems in accordance with their now more supportive living situations.
methodsThis cross-sectional study examined the hypothalamic-pituitary-adrenocortical (HPA)-axis reactivity of 280 children ages 7 through 14 years; 122 children were adopted from institutions in 14 countries between the ages of 6 months and 5 years, after spending an average of 95% of their lives in institutional care, and 158 children of similarly high socioeconomic status in their biological families served as the nonadopted comparison group. All of the children were assessed by nurses for Tanner stage and, on a different day, completed the Trier Social Stress Test for Children.
resultsUsing a linear mixed-effects model and seven measures of salivary cortisol, results indicated that early-pubertal postinstitutionalized children showed blunted HPA axis reactivity compared to nonadopted children, but mid/late-pubertal postinstitutionalized children displayed higher reactivity similar to the nonadopted comparison children.
conclusionsThis is the first evidence of possible pubertal recalibration of HPA axis reactivity to a psychosocial stressor in postinstitutionalized children, which provides a promising avenue for future research regarding the protective factors of the postadoption environment and subsequent physiological, behavioral, and psychopathological outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.