ArticleEnvironmental science and pollution research international2018
Effect of PM2.5 environmental pollution on rat lung.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- Particulate Matter Exposure and Viral Infections: Relevance to Highly Polluted Settings such as Ulaanbaatar, Mongolia.Current environmental health reports · 2025Review
- PM2.5 Exposure Aggravates Inflammatory Response and Mucus Production in 16HBE Cells through Inducing Oxidative Stress and RAGE Expression.Cell biochemistry and biophysics · 2025Article
- Protective Effects of Atractylodis Rhizoma Extracts on Lung Injury Induced by Particulate Matter 2.5 in Mice.Antioxidants (Basel, Switzerland) · 2025Article
- Effect of the S100A9/AMPK pathway on PM2.5-mediated mouse lung injury.Iranian journal of basic medical sciences · 2025Article
- Exendin-4 blockade of T1R2/T1R3 activation improves Pseudomonas aeruginosa-related pneumonia in an animal model of chemically induced diabetes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Estimating PMScientific reports · 2023Article
- Article
- Acute and subchronic exposure to urban atmospheric pollutants aggravate acute respiratory failure in infants.Scientific reports · 2023Article
- Toxicological Effects of Fine Particulate Matter (PMWater, air, and soil pollution · 2023Review
- Toxicity evaluation in rats following 28 days of inhalation exposure to xylitol aerosol.Toxicology research · 2021Article
- Glomerular function in relation to fine airborne particulate matter in a representative population sample.Scientific reports · 2021Article
- Environmentally Relevant Iron Oxide Nanoparticles Produce Limited Acute Pulmonary Effects in Rats at Realistic Exposure Levels.International journal of molecular sciences · 2021Article
- Explore Regional PM2.5 Features and Compositions Causing Health Effects in Taiwan.Environmental management · 2021Article
- Cellular effects of PMEnvironmental science and pollution research international · 2021Article
- Astragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K/Akt/mTOR Signaling in vivo and in vitro.Journal of inflammation research · 2021Article
- Amelioration of Ambient Particulate Matter (PMFrontiers in physiology · 2021Article
- Impact of Air Pollution on Residents' Medical Expenses: A Study Based on the Survey Data of 122 Cities in China.Frontiers in public health · 2021Article
- Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.Molecular medicine reports · 2020Article
- An ensemble learning based hybrid model and framework for air pollution forecasting.Environmental science and pollution research international · 2020Article
- Construction of polluted aerosol in accumulation that affects the incidence of lung cancer.Heliyon · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Particulate matter smaller than 2.5 μm (PM2.5) is a continuing challenge to pulmonary health. Here, we investigated the mechanisms involved in PM2.5 exposure-induced acute lung injury in rats. We analyzed biochemical and morphological changes following a 2-week "real-world" exposure. And then we found that PM2.5 exposure increased the concentrations of total protein, malondialdehyde, hydrogen peroxide, nitric oxide, and soluble elastin in bronchoalveolar lavage fluid, levels of cytokines in blood, and expression of MMP-9 in airways. Further, alveolar macrophage and neutrophil counts increased following PM2.5 exposure, and edema and lung lesions were observed. Our results suggest that PM2.5 exposure can induce oxidative stress and acute inflammatory responses, which can damage the micro-environment and decrease the repair ability of the lung, resulting in tissue damage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.