Evidence map›Paper›PMID 30357685›Full record

ArticleAdvances in experimental medicine and biology

Novel Biomimetic Microphysiological Systems for Tissue Regeneration and Disease Modeling.

Karim I Budhwani, Patsy G Oliver, Donald J Buchsbaum, Vinoy Thomas

Abstract read
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Article in Advances in experimental medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A hitchhiker's guide to cancer models.Trends in biotechnology · 2022
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karim I BudhwaniDepartments of Radiation Oncology and Materials Science & Engineering, The University of Alabama at Birmingham, Birmingham, AL, USA.
Patsy G OliverDepartment of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Donald J BuchsbaumDepartment of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Vinoy ThomasDepartment of Materials Science & Engineering, The University of Alabama at Birmingham, Birmingham, AL, USA. vThomas@uab.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomaterials engineered to closely mimic morphology, architecture, and nanofeatures of naturally occurring in vivo extracellular matrices (ECM) have gained much interest in regenerative medicine and in vitro biomimetic platforms. Similarly, microphysiological systems (MPS), such as lab-chip, have drummed up momentum for recapitulating precise biomechanical conditions to model the in vivo microtissue environment. However, porosity of in vivo scaffolds regulating barrier and interface functions is generally absent in lab-chip systems, or otherwise introduces considerable cost, complexity, and an unrealistic uniformity in pore geometry. We address this by integrating electrospun nanofibrous porous scaffolds in MPS to develop the lab-on-a-brane (LOB) MPS for more effectively modeling transport, air-liquid interface, and tumor progression and for personalized medicine applications.

Indexed as

BiomimeticsNanofibersRegenerative MedicineTissue ScaffoldsHumansRegenerationTissue Engineeringatomizationdisease modelelectrohydrodynamicelectrospinningmicrophysiological systemsNanomedicinenanotechnologytissue engineering

Identifiers

PMID30357685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.