ReviewAdvances in experimental medicine and biology
Modulation of the Osteoimmune Environment in the Development of Biomaterials for Osteogenesis.
Review in Advances in experimental medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Trial
- Development of Hydroxyapatite as a Bone Implant Biomaterial for Triggering Osteogenesis.European journal of dentistry · 2026Article
- Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review.Tissue engineering and regenerative medicine · 2025Review
- Article
- Macrophages in guided bone regeneration: potential roles and future directions.Frontiers in immunology · 2024Review
- Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration.Materials today. Bio · 2022Review
- Osteocyte-Mediated Translation of Mechanical Stimuli to Cellular Signaling and Its Role in Bone and Non-bone-Related Clinical Complications.Current osteoporosis reports · 2020Review
- The Role of Autophagy in M2 Polarization of Macrophages Induced by Micro/Nano Topography.International journal of nanomedicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of inherent regenerative ability of bone, large amounts of fracture patients still display delayed or compromised bone healing due to patients' age status, trauma severity or the developmental anomalies or infections, which requires therapeutic intervention. Bone regeneration involves different cells (immune cells, progenitors and mesenchymal stem cells, etc) and subsequent signaling molecules (chemokines, cytokines and growth factors, etc). The quantity and quality of immune cells influx into the site of injury and the subsequent cytokine production form a unique osteoimmune environment. Current strategies on repairing bone defects have largely focused on the development of suitable bone substitute materials, which may have potential osteoinductive, and/or osteoconductive properties. Various studies have been reported to develop the immuno-active or immunomodulatory biomaterials, which could fully explore the early osteoimmune environment in order to achieve better bone regeneration.
Indexed as
Identifiers
30357684What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.