Evidence map›Paper›PMID 30357568›Full record

ArticleMolecular imaging and biology2019

[

Giacomo Pirovano, Sheryl Roberts, Christian Brand, Patrick L Donabedian, Christian Mason, Paula Demétrio de Souza, Geoff S Higgins, Thomas Reiner

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Improved radiosynthesis ofInternational journal of radiation biology · 2023
    Article
  4. Review
  5. Review
  6. Article
  7. PET/CT Imaging with anJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  8. TOPKi-NBD: a fluorescent small molecule for tumor imaging.European journal of nuclear medicine and molecular imaging · 2020
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Giacomo PirovanoDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Sheryl RobertsDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Christian BrandDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Patrick L DonabedianDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Christian MasonDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Paula Demétrio de SouzaDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
Geoff S HigginsCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
Thomas ReinerDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. reinert@mskcc.org.ORCID 0000-0002-7819-5480
Memorial Sloan Kettering Cancer Center · USUniversity of Oxford · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
Cancer Research UK 19590NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204441
6 · The paper itself

Abstract

purposeLymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) imaging allowing more accurate patient identification, stratification, and disease monitoring. PROCEDURES: [

results[

conclusions[

Indexed as

Positron-Emission TomographyXenograft Model Antitumor AssaysAnimalsBrain NeoplasmsCell Line, TumorGlioblastomaHalf-LifeHumansMiceMitogen-Activated Protein Kinase KinasesProtein Kinase InhibitorsQuinolonesRadiopharmaceuticalsSmall Molecule LibrariesMitogen-Activated Protein Kinase KinasesOTS964Protein Kinase InhibitorsQuinolonesRadiopharmaceuticalsSmall Molecule LibrariesTOPK protein, mouseGlioblastomaMolecular imagingOTS964PETTOPK

Identifiers

PMID30357568
PMCPMC6482100
OpenAlexW2898494641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.