ArticleVirchows Archiv : an international journal of pathology2019
Histopathology of livers in patients with congenital portosystemic shunts (Abernethy malformation): a case series of 22 patients.
Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Congenital portosystemic shunt (CPSS)/Abernethy malformation: morpho-molecular aspects of a rare hepatic tumour risk disease.Virchows Archiv : an international journal of pathology · 2026Article
- Recapitulating Liver Embryology-Lessons to Be Learned for Liver Diseases.Journal of developmental biology · 2025Review
- High Frequency ofLiver cancer · 2025Article
- Fetal Extrahepatic Portosystemic Venous Shunts: Prenatal Diagnosis Management and Therapy - 21 Years of Evolving Insights.Fetal diagnosis and therapy · 2025Article
- Regenerative nodules as harbinger of Abernethy malformation.BMJ case reports · 2023Article
- Unexplained hyperammonemia and encephalopathy in the emergency department: Abernethy malformation in elderly patients.World journal of emergency medicine · 2023Article
- [Analysis of clinical features of 380 cases of special portal hypertension-Abernethy malformation].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- AiLIVER · 2022Review
- A rare presentation of type II Abernethy malformation and nephrotic syndrome: Case report and review.Open life sciences · 2022Article
- Vascular anomalies associated with hepatic shunting.World journal of gastroenterology · 2020Review
- Lobular diameters of autopsied dog livers give clues for an appropriate liver biopsy methodology.The Journal of veterinary medical science · 2020Article
- Case Report: Hepatic Adenoma in a Child With a Congenital Extrahepatic Portosystemic Shunt.Frontiers in pediatrics · 2020Article
- Patent ductus venosus in an infant with direct hyperbilirubinemia.Clinical case reports · 2019Article
- EUS-guided coil placement and cyanoacrylate glue injection for gastric variceal bleeding with obvious spontaneous portosystemic shunts.Endoscopic ultrasoundArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital portosystemic shunt (CPSS) is a congenital anomaly resulting in partial or complete diversion of the portal blood into the systemic circulation. The literature on the histological changes in livers of patients with CPSS is limited. Liver histology of 22 consecutive patients managed in our institution between 2001 and 2016 was reviewed. Twenty-one patients were children at the time of diagnosis. Thirty-two specimens were available and consisted of three explant livers and 29 biopsy samples from 19 patients. Sixteen samples were from wedge biopsies taken at the time of shunt closure. Thirteen were from core needle biopsies taken during clinical work-up. A variable proportion of portal tracts contained prominent thin-walled channels (PTWCs) and arterio-biliary dyads. The proportion of portal tracts containing triads, arterio-biliary dyads and biliary monads varied considerably in the different samples. Dilated inlet venules, increase in the number of portal arteries or the presence of portal arteries of increased size, deposition of copper-associated protein, sinusoidal dilatation, capillarization and intralobular individual arteries were present. Physiological nuclear vacuolation of periportal hepatocytes was absent in most samples from our paediatric patients. Presence of PTWCs, arterial-biliary dyads, increased arterial profiles in portal tracts and lobule and lack of the physiological periportal vacuolated hepatocytes in children are the most characteristic histological changes of CPSS in the liver periphery.
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