ArticleJournal of community hospital internal medicine perspectives2018
Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review.
Article in Journal of community hospital internal medicine perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Toxicity of psychotropic drugs in patients with COVID-19: A systematic review.General hospital psychiatryPooled it
- Hepatic adverse effects of valproic acid: Management strategies.Indian journal of pharmacology · 2026Article
- Drug-induced liver injury during valproic acid and cenobamate coadministration: a direct consequence or an unforeseen event?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Advancements in Valproate Therapy for Seizures, Migraines, and Bipolar Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- The role of SIRT1-FXR signaling pathway in valproic acid induced liver injury: a quantitative targeted metabolomic evaluation in epileptic children.Frontiers in pharmacology · 2024Article
- A comprehensive review on pharmacological applications and drug-induced toxicity of valproic acid.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Review
- Evaluation of the Effect of Alcoholic Extract ofArchives of Razi Institute · 2022Article
- Management of Psychiatric Disorders in Patients with Hepatic and Gastrointestinal Diseases.Indian journal of psychiatry · 2022Article
- Valproic acid for children below 2 years of age with epilepsy.Neurosciences (Riyadh, Saudi Arabia) · 2021Article
- Hyperammonemia in patients receiving valproic acid in the hospital setting: A retrospective review.The mental health clinician · 2021Article
- Preliminary Results Regarding Sleep in a Zebrafish Model of Autism Spectrum Disorder.Brain sciences · 2021Article
- Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents.Frontiers in immunology · 2021Review
- Article
- Infrequent Monitoring of the Effects of Valproate and Carbamazepine Therapy in Patients With Epilepsy in Nigeria.Journal of central nervous system disease · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Valproic acid (VPA) is a commonly used agent in the management of seizures and psychiatric disorders. Hyperammonemia is a common complication of VPA with 27.8% of patients having elevated levels - that is unrelated to hepatotoxicity and normal transaminases. Common side effects include obesity, insulin resistance, metabolic disorder and severe forms of hepatotoxicity. Other rare and idiosyncratic reactions have been reported, one of which is presented in our case. A 27-year old patient presented with hyperammonemia and encephalopathy as a consequence of idiosyncratic VPA reaction causing drug-induced liver injury (DILI) with severely elevated transaminases. DILI is commonly overlooked when investigating encephalopathy in the setting of VPA. Physicians should consider DILI in the context of hyperammonemia and transaminitis.
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Registered trials
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