Evidence map›Paper›PMID 30356942›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018

Polydopamine-Modified Black Phosphorous Nanocapsule with Enhanced Stability and Photothermal Performance for Tumor Multimodal Treatments.

Xiaowei Zeng, Miaomiao Luo, Gan Liu, Xusheng Wang, Wei Tao, Yaoxin Lin, Xiaoyuan Ji, Lin Nie, Lin Mei

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 1 synthesis or guideline pooled it.

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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaowei ZengSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.
Miaomiao LuoSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.
Gan LiuSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.
Xusheng WangSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.
Wei TaoBrigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.
Yaoxin LinSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.
Xiaoyuan JiSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.
Lin NieSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.
Lin MeiSchool of Pharmaceutical Sciences (Shenzhen) Sun Yat-sen University Guangzhou 510275 China.ORCID 0000-0001-6503-5149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a novel 2D material, black phosphorus (BP) nanosheets are considered as a promising candidate for drug delivery platform for synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP poses a challenge in its biomedical applications. To date, some strategies have been employed to prevent BP from rapid ambient degradation. Unfortunately, most of these strategies are not suitable for the drug delivery systems. Here, a simple polydopamine modification method is developed to enhance the stability and photothermal performance of bare BP nanosheets. Then, this nanocapsule is used as a multifunctional codelivery system for the targeted chemo, gene, and photothermal therapy against multidrug-resistant cancer. The enhanced tumor therapy effect is demonstrated by both in vitro and in vivo studies.

Indexed as

black phosphorus nanosheetsenhanced stabilitymultimodal treatmentspolydopamine

Identifiers

PMID30356942
PMCPMC6193171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.