Evidence map›Paper›PMID 30356899›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018

Simple and Low-Cost Sampling of Cell-Free Nucleic Acids from Blood Plasma for Rapid and Sensitive Detection of Circulating Tumor DNA.

Choong Eun Jin, Bonhan Koo, Tae Yoon Lee, Kyudong Han, Seok Byung Lim, In Ja Park, Yong Shin

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Improving electrochemical hybridization assays with restriction enzymes.Chemical communications (Cambridge, England) · 2024
    Article
  9. A non-invasive, sensitive assay for active TB: combined cell-free DNA detection and FluoroSpot assays.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Choong Eun JinDepartment of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine 88 Olympicro-43gil, Songpa-gu ,05505 Seoul Republic of Korea.
Bonhan KooDepartment of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine 88 Olympicro-43gil, Songpa-gu ,05505 Seoul Republic of Korea.
Tae Yoon LeeDepartment of Technology Education and Department of Biomedical Engineering Chungnam National University 99 Daehak-ro, Yuseong-gu Daejeon 34134 Republic of Korea.
Kyudong HanDepartment of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook University Cheonan 31116 Republic of Korea.
Seok Byung LimDepartment of Colon & Rectal Surgery Asan Medical Center University of Ulsan College of Medicine 88 Olympicro-43gil, Songpa-gu ,05505 Seoul Republic of Korea.
In Ja ParkDepartment of Colon & Rectal Surgery Asan Medical Center University of Ulsan College of Medicine 88 Olympicro-43gil, Songpa-gu ,05505 Seoul Republic of Korea.
Yong ShinDepartment of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine 88 Olympicro-43gil, Songpa-gu ,05505 Seoul Republic of Korea.ORCID 0000-0002-7426-4717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-free nucleic acids (cfNAs) are emerging diagnostic biomarkers for monitoring the treatment and recurrence of cancers. In particular, the biological role and clinical usefulness of cfNAs obtained from the plasma of patients with various cancers are popular and still intensely explored, yet most studies are limited by technical problems during cfNA isolation. A dimethyl dithiobispropionimidate (DTBP)-based microchannel platform that enables spontaneous cfNA capture in 15 min with minimal cellular background and no requirements for use of bulky instruments is reported first. This platform identified

Indexed as

biooptical sensorscell‐free nucleic acidscirculating tumor DNAliquid biopsymicrofluidics platforms

Identifiers

PMID30356899
PMCPMC6193143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.