ArticleJournal of animal science and biotechnology2018
Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle.
Article in Journal of animal science and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.The veterinary quarterly · 2026Article
- Metabolomic and transcriptomic landscape of the bovine uterine lumen during the second week of the estrous cycle.Journal of animal science and biotechnology · 2026Article
- Dietary Supplementation of Rumen-Inert Fatty Acids and Rumen-Protected Choline Modulates the Uterine Environment of Pregnant Beef Cows.Molecular reproduction and development · 2026Article
- PGEAnimals : an open access journal from MDPI · 2026Article
- Fertility classification of the cow and peri-estrus sex-steroid hormones is associated with endometrial epithelial cell responses to conceptus and inflammatory signals.Cell and tissue research · 2026Article
- Roe deer uterine fluid metabolome reveals elevated glycolysis, fatty acid breakdown, and spermidine synthesis upon reactivation from diapause†.Biology of reproduction · 2025Article
- Bovine Genital Leptospirosis: An Update of This Important Reproductive Disease.Animals : an open access journal from MDPI · 2024Review
- Differing planes of nutrition alter serum and histotroph amino acid composition in nonpregnant, multiparous beef cows on day 3 of the estrous cycle.Journal of animal science · 2024Article
- Characterization of bovine uterine fluid extracellular vesicles proteomic profiles at follicular and luteal phases of the oestrous cycle.Veterinary research communications · 2023Article
- Ovulation Induced by Intrauterine Seminal Plasma Increases Total Protein, PGE2, IL-8, and IL-1β in Uterine Fluid of Llamas (Animals : an open access journal from MDPI · 2023Article
- Bioactive supplements influencing bovine in vitro embryo development.Journal of animal science · 2022Review
- Progesterone-dependent and progesterone-independent modulation of luminal epithelial transcription to support pregnancy in cattle.Physiological genomics · 2022Article
- Endometrial receptivity in cattle: the mutual reprogramming paradigm.Animal reproduction · 2022Review
- Effect of Endometrial Sampling Procedures on Subsequent Pregnancy Rate of Cattle.Animals : an open access journal from MDPI · 2021Review
- Concentration-Dependent Type 1 Interferon-Induced Regulation of MX1 and FABP3 in Bovine Endometrial Explants.Animals : an open access journal from MDPI · 2021Article
- Maternal periconceptual nutrition, early pregnancy, and developmental outcomes in beef cattle.Journal of animal science · 2020Review
- The incompletely fulfilled promise of embryo transfer in cattle-why aren't pregnancy rates greater and what can we do about it?Journal of animal science · 2020Review
- Bacterial taxonomic composition of the postpartum cow uterus and vagina prior to artificial insemination1.Journal of animal science · 2019Article
- The pre-hatching bovine embryo transforms the uterine luminal metabolite composition in vivo.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA major, unresolved issue is how the uterine microenvironment determines pregnancy success in cattle. Before implantation, conceptus development depends on the uterine secretome (i.e., histotroph). Despite its pivotal role, little is known about the dynamics of histotroph synthesis and changes in composition throughout the early diestrus and the relevance to pregnancy establishment. We hypothesize that disturbances on histotroph composition affect the establishment of pregnancy. Aim was to disturb histotroph composition at early diestrus and verify the effects on: (Exp. 1) timing to restore its composition; and (Exp. 2) pregnancy rate after multiple-embryo transfer. Estrous cycle of multiparous Nelore cows were synchronized and estrus was considered d 0 (D0) of the experiments. Disturbance was through flushing each uterine horn with 30 mL of DMPBS and collecting the resulting uterine luminal flushing (ULF) on D1; D4; D7; D1 + D4 + D7. Control group remained not-collected. In Exp. 1, ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of albumin. In Exp. 2, three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the CL on D7.5 and pregnancy was checked on D25 by ultrasound.
resultsIn Exp. 1, ULF collection on D4 or D7 increased (1.5- to 2.2-folds) the total protein concentration and albumin abundance. ULF collection on D1 did not alter (
conclusionsSubtle perturbations imposed to the native intrauterine milieu, such as those caused by a single, low-volume collection of ULF, profoundly disturbs intrauterine composition and pregnancy success. At least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.
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