Evidence map›Paper›PMID 30356792›Full record

ArticleFrontiers in immunology2018

Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis.

Xiaohua Hao, Yufeng Li, Jianwen Wang, Jiali Ma, Shuli Zhao, Xiaohui Ye, Lingling He, Junru Yang, Meixin Gao, Fan Xiao and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. d-Sorbose Promotes Regulatory T-Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  14. The Beginner's Guide toFrontiers in immunology · 2022
    Review
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  16. Article
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  18. Review
  19. O-GlcNAcylation and its role in the immune system.Journal of biomedical science · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xiaohua HaoBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Yufeng LiBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Jianwen WangBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Jiali MaBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Shuli ZhaoCentral Laboratory of Nanjing First hospital, Nanjing Medical University, Nanjing, China.
Xiaohui YeBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Lingling HeBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Junru YangBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Meixin GaoBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Fan XiaoBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Hongshan WeiBeijing Ditan Hospital, Capital Medical University, Beijing, China.
Beijing Ditan Hospital · CNCapital Medical University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-translational modifications such as glycosylation play an important role in the functions of homeostatic proteins, and are critical driving factors of several diseases; however, the role of glycosylation in autoimmune hepatitis is poorly understood. Here, we established an O-GlcNAc glycosylation-deficient rat model by knocking out the

Indexed as

AcetylglucosamineAnimalsCell DifferentiationConcanavalin ADisease Models, AnimalGene Knockout TechniquesGlycosylationHepatitis, AutoimmuneLiverLymphocyte ActivationN-AcetylglucosaminyltransferasesProtein Processing, Post-TranslationalRatsRats, Sprague-DawleyReceptors, NotchSignal TransductionAcetylglucosamineConcanavalin AN-AcetylglucosaminyltransferasesReceptors, Notchautoimmune hepatitisEOGTnotch signaling pathwayO-GlcNAc glycosylationtreg cells

Identifiers

PMID30356792
PMCPMC6189470
OpenAlexW2897722343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.