ArticleFrontiers in microbiology2018
Root Microbiota in Primary and Secondary Apical Periodontitis.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06164509 (Healing Potentiality of Different Doses of Trypsin and Alpha Chemo Trypsin in Mandibular Molars With Chronic Apical Abscess), which is not on this map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Healing Potentiality of Different Doses of Trypsin and Alpha Chemo Trypsin in Mandibular Molars With Chronic Apical Abscess
Who cites it
71 citing papers in PubMed, 142 citations in OpenAlex.
- Protocols to evaluate the antibacterial and irrigation efficacy of new root canal irrigants: A systematic review of ex vivo studies.The Japanese dental science review · 2026Review
- Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study.International endodontic journal · 2026Observational
- Laboratory investigation of intra-tooth variability in microbial communities from clinically isolated root canal and filling material.Clinical oral investigations · 2026Article
- Effect of chitosan medicaments loaded with green-synthesized silver nanoparticles on basic fibroblast growth factor release from infected dentin.Odontology · 2026Article
- Microbial dynamics in primary and refractory apical periodontitis: Next-generation 16S rRNA sequencing reveals selective shifts and reduced diversity.Journal of conservative dentistry and endodontics · 2026Article
- Microbiome of Apical Intracanal and Extraradicular Biofilms From the Same Roots of Teeth With Persistent Apical Periodontitis: An Observational Study.International endodontic journal · 2026Observational
- Quantitative PCR-Based Analysis of Bacterial Profiles in Periapical Lesions and Maxillary Sinus in Odontogenic Sinusitis.International journal of molecular sciences · 2026Article
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Distinct bacteria profiles in primary and secondary/persistent endodontic infections: a 16S rRNA gene sequencing study.BMC oral health · 2026Article
- Efficacy of Bioceramic Cements Versus Conventional Cements in the Prognosis of Endodontic Treatments in Patients with Apical Periodontitis: A Systematic Review with Meta-Analysis.Iranian endodontic journal · 2026Review
- Profiling of microbes associated with chronic irreversible pulpitis using metagenomic next-generation sequencing.BMC oral health · 2025Article
- Effect of membrane vesicles produced under different pH conditions on the ability ofJournal of bacteriology · 2025Article
- Exploring Relationships Within the Microbiome of Root Canal Infections and the Influence of Associated Clinical Parameters.International endodontic journal · 2025Article
- Application of on-demand aqueous chlorine dioxide solution for non-surgical root canal treatment.Scientific reports · 2025Article
- Modulation of primary human apical papilla stem cells: Influence of Enterococcus faecalis, oxygen levels, and calcium silicate-based cements.European journal of oral sciences · 2025Article
- The Role of Nrf2 in the Regulation of Periodontitis, Peri-implantitis, Dentin Infection, and Apical Periodontitis.Biological procedures online · 2025Review
- Characterization and ex vivo modelling of endodontic infections from the Arabian Gulf region.International endodontic journal · 2025Article
- Bacterial genera in the fluids from apical periodontitis-related radicular cysts: An observational study.International endodontic journal · 2025Observational
- A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections.NPJ biofilms and microbiomes · 2025Review
- Microbiota of Healthy Dental Pulp Under the Omics Loupe.International journal of molecular sciences · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apical periodontitis is an inflammatory disease of the dental periradicular tissues triggered by bacteria colonizing necrotic root canals. Primary apical periodontitis results from the microbial colonization of necrotic pulp tissues. Secondary apical periodontitis results from a persistent infection of incorrectly treated root canals. The aim of this study was to characterize the microbiota present in primary and secondary intraradicular infections associated with apical periodontitis using 16S rRNA gene amplicon sequencing. Teeth exhibiting apical periodontitis with or without root canal treatment were extracted after informed consent. From each tooth, the intraradicular content as well as a dentin sample (control) were collected and subjected to DNA extraction. PCR amplicons of the V3-V4 region of the bacterial 16S rRNA gene were pooled and sequenced (2 × 300) on an Illumina MiSeq instrument. The bioinformatics analysis pipeline included quality filtering, merging of forward and reverse reads, clustering of reads into operational taxonomic units (OTUs), removal of putative contaminant OTUs and assigning taxonomy. The most prevalent and abundant OTU in both dentin and root canal samples was assigned to anaerobic bacterium
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.