ReviewFrontiers in pediatrics2018
Autonomic Nervous System Dysfunction in Pediatric Sepsis.
Review in Frontiers in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04100486 (A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Heart Rate Variability Analysis to Evaluate Autonomic Nervous System Maturation in Neonates: An Expert Opinion.Frontiers in pediatrics · 2022Pooled it
- A novel index for trending sepsis and inflammatory response using processed EEG and Heart Rate Variability.Journal of clinical monitoring and computing · 2026Observational
- Autonomic and neural responses to varying transcutaneous cervical electrical stimulation parameters.Bioelectronic medicine · 2026Article
- Septic Cardiomyopathy: Age-Dependent Physiology and Hemodynamic Aspects-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Electrochemical skin conductance is associated with peripheral tissue hypoperfusion in septic patients.Intensive care medicine experimental · 2025Article
- Assessing bedside measures of autonomic nervous system dysregulation in the PICU.Pediatric research · 2025Observational
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Artificial intelligence in pediatric intensive care: unlocking integrated monitoring for autonomic nervous system dysregulation.Pediatric research · 2025Article
- Sleep in Juvenile Idiopathic Arthritis: An Exploratory Investigation of Heart Rate Variability.Brain sciences · 2025Article
- Combatting sepsis-induced myocardial dysfunction: emerging mechanisms and immunomodulatory breakthroughs.Frontiers in immunology · 2025Review
- Blockade of sympathetic ganglia improves vascular dysfunction in septic shock.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Article
- Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits.Brain, behavior, and immunity · 2024Article
- Transforming neonatal care with artificial intelligence: challenges, ethical consideration, and opportunities.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Microcirculation and Mitochondria: The Critical Unit.Journal of clinical medicine · 2023Review
- Inflammatory mechanisms and intervention strategies for sepsis-induced myocardial dysfunction.Immunity, inflammation and disease · 2023Review
- Heart rate variability is associated with encephalopathy and outcomes in pediatric acute liver failure.Pediatric research · 2023Observational
- Adding heart rate n-variability (HRnV) to clinical assessment potentially improves prediction of serious bacterial infections in young febrile infants at the emergency department: a prospective observational study.Annals of translational medicine · 2023Article
- Novel approaches to capturing and using continuous cardiorespiratory physiological data in hospitalized children.Pediatric research · 2023Review
- Autonomic and circulatory alterations persist despite adequate resuscitation in a 5-day sepsis swine experiment.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The autonomic nervous system (ANS) plays a major role in maintaining homeostasis through key adaptive responses to stress, including severe infections and sepsis. The ANS-mediated processes most relevant during sepsis include regulation of cardiac output and vascular tone, control of breathing and airway resistance, inflammation and immune modulation, gastrointestinal motility and digestion, and regulation of body temperature. ANS dysfunction (ANSD) represents an imbalanced or maladaptive response to injury and is prevalent in pediatric sepsis. Most of the evidence on ANSD comes from studies of heart rate variability, which is a marker of ANS function and is inversely correlated with organ dysfunction and mortality. In addition, there is evidence that other measures of ANSD, such as respiratory rate variability, skin thermoregulation, and baroreflex and chemoreflex sensitivity, are associated with outcomes in critical illness. The relevance of understanding ANSD in the context of pediatric sepsis stems from the fact that it might play an important role in the pathophysiology of sepsis, is associated with outcomes, and can be measured continuously and noninvasively. Here we review the physiology and dysfunction of the ANS during critical illness, discuss methods for measuring ANS function in the intensive care unit, and review the diagnostic, prognostic, and therapeutic value of understanding ANSD in pediatric sepsis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.