Evidence map›Paper›PMID 30356648›Full record

ReviewJournal of sport and health science2018

Basic science and clinical use of eccentric contractions: History and uncertainties.

Kiisa C Nishikawa, Stan L Lindstedt, Paul C LaStayo

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of sport and health science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Neurophysiology of ACL Injury.Orthopedic reviews · 2025
    Article
  7. Review
  8. Review
  9. Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics.Pflugers Archiv : European journal of physiology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Eccentric Exercise: Adaptations and Applications for Health and Performance.Journal of functional morphology and kinesiology · 2021
    Review
  14. Acute and Delayed Effects of Time-Matched Very Short "All Out" Efforts in Concentric vs. Eccentric Cycling.International journal of environmental research and public health · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. N2A Titin: Signaling Hub and Mechanical Switch in Skeletal Muscle.International journal of molecular sciences · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kiisa C NishikawaCenter for Bioengineering Innovation and Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.
Stan L LindstedtCenter for Bioengineering Innovation and Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.
Paul C LaStayoDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 86011, USA.
Northern Arizona University · USUniversity of Utah · US

Funding

Reducing Falls with RENEW in Older Individuals Who Have FallenR01AG031255 · NIA · UNIVERSITY OF UTAH · PI LASTAYO, PAUL C · 2008 to 2012
$2.2M
A RENEW Intervention for Elderly Cancer SurvivorsR21CA114523 · NCI · UNIVERSITY OF UTAH · PI LASTAYO, PAUL C · 2006 to 2007
$308k
High-force eccentric exercise for sarcopeniaR21AG018701 · NIA · NORTHERN ARIZONA UNIVERSITY · PI LINDSTEDT, STAN L · 2001 to 2002
$249k
NCI NIH HHS R21 CA114523NIA NIH HHS R01 AG031255NIA NIH HHS R21 AG018701
6 · The paper itself

Abstract

The peculiar attributes of muscles that are stretched when active have been noted for nearly a century. Understandably, the focus of muscle physiology has been primarily on shortening and isometric contractions, as eloquently revealed by A.V. Hill and subsequently by his students. When the sliding filament theory was introduced by A.F. Huxley and H.E. Huxley, it was a relatively simple task to link Hill's mechanical observations to the actions of the cross bridges during these shortening and isometric contractions. In contrast, lengthening or eccentric contractions have remained somewhat enigmatic. Dismissed as necessarily causing muscle damage, eccentric contractions have been much more difficult to fit into the cross-bridge theory. The relatively recent discovery of the giant elastic sarcomeric filament titin has thrust a previously missing element into any discussion of muscle function, in particular during active stretch. Indeed, the unexpected contribution of giant elastic proteins to muscle contractile function is highlighted by recent discoveries that twitchin-actin interactions are responsible for the "catch" property of invertebrate muscle. In this review, we examine several current theories that have been proposed to account for the properties of muscle during eccentric contraction. We ask how well each of these explains existing data and how an elastic filament can be incorporated into the sliding filament model. Finally, we review the increasing body of evidence for the benefits of including eccentric contractions into a program of muscle rehabilitation and strengthening.

Indexed as

ExerciseForce enhancementMuscle mechanicsRehabilitationTitin/connectin

Identifiers

PMID30356648
PMCPMC6189250
OpenAlexW2809586834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.