ArticleJournal of sport and health science2018
Titin-mediated thick filament activation stabilizes myofibrils on the descending limb of their force-length relationship.
Article in Journal of sport and health science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Modeling thick filament activation suggests a molecular basis for force depression.Biophysical journal · 2024Article
- What Can We Learn from Single Sarcomere and Myofibril Preparations?Frontiers in physiology · 2022Review
- Sarcomere Lengths Become More Uniform Over Time in Intact Muscle-Tendon Unit During Isometric Contractions.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
purposeThe aim of this study was to extend current half-sarcomere models by involving a recently found force-mediated activation of the thick filament and analyze the effect of this mechanosensing regulation on the length stability of half-sarcomeres arranged in series.
methodsWe included a super-relaxed state of myosin motors and its force-dependent activation in a conventional cross-bridge model. We simulated active stretches of a sarcomere consisting of 2 non-uniform half-sarcomeres on the descending limb of the force-length relationship.
resultsThe mechanosensing model predicts that, in a passive sarcomere on the descending limb of the force-length relationship, the longer half-sarcomere has a higher fraction of myosin motors in the on-state than the shorter half-sarcomere. The difference in the number of myosin motors in the on-state ensures that upon calcium-mediated thin filament activation, the force-dependent thick filament activation keeps differences in active force within 20% during an active stretch. In the classical cross-bridge model, the corresponding difference exceeds 80%, leading to great length instabilities.
conclusionOur simulations suggest that, in contrast to the classical cross-bridge model, the mechanosensing regulation is able to stabilize a system of non-uniform half-sarcomeres arranged in series on the descending limb of the force-length relationship.
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