ArticleJournal of sport and health science2017
Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise.
Article in Journal of sport and health science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
- Evaluating the Effectiveness of a Hybrid Tai Chi Cardiac Rehabilitation Programme for Psychological Stress Reduction and Oxidative Stress in Patients With Chronic Coronary Syndrome: A Randomized Controlled Trial.Stress and health : journal of the International Society for the Investigation of Stress · 2025Trial
- Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22International journal of environmental research and public health · 2020Trial
- Molecular mechanisms of blood-brain barrier dysfunction caused by obesity: pathophysiological understandings and treatment targets.Metabolic brain disease · 2026Review
- Individual response to continuous and interval training on cognitive and brain-derived neurotrophic factor in adolescents with overweight/obesity.Pediatric research · 2026Article
- Acupoint catgut embedding exerts node-dependent effects on leptin resistance-related signaling and the ghrelin-GOAT pathway in obese mice.Frontiers in nutrition · 2026Article
- A moderate lard-included diet reduces fat deposition and inflammation in the adipose tissue.NPJ science of food · 2025Article
- Oxidative stress in diabetes mellitus and its complications: From pathophysiology to therapeutic strategies.Chinese medical journal · 2025Review
- Luteolin-7-O-β-d-Glucuronide Attenuated Cerebral Ischemia/Reperfusion Injury: Involvement of the Blood-Brain Barrier.Biomedicines · 2024Article
- Cardiometabolic risk factors and neurodegeneration: a review of the mechanisms underlying diabetes, obesity and hypertension in Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry · 2024Review
- Review
- The effect of high-intensity intermittent and moderate-intensity continuous exercises on neurobiological markers and cognitive performance.BMC sports science, medicine & rehabilitation · 2024Article
- Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications.Frontiers in allergy · 2024Review
- Metabolic Profile of Alzheimer's Disease: Is 10-Hydroxy-2-decenoic Acid a Pertinent Metabolic Adjuster?Metabolites · 2023Review
- Diet's Role in Modifying Risk of Alzheimer's Disease: History and Present Understanding.Journal of Alzheimer's disease : JAD · 2023Review
- Factors of Obesity and Metabolically Healthy Obesity in Asia.Medicina (Kaunas, Lithuania) · 2022Review
- Zebrafish: A New Promise to Study the Impact of Metabolic Disorders on the Brain.International journal of molecular sciences · 2022Review
- Cardiovascular Risk Factors and Physical Activity for the Prevention of Cardiovascular Diseases in the Elderly.International journal of environmental research and public health · 2021Review
- Oxidative stress and neuroinflammation in a rat model of co-morbid obesity and psychogenic stress.Behavioural brain research · 2021Article
- Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients.Journal of neurotrauma · 2021Review
- Inflammation, oxidative stress, insulin resistance, and hypertension as mediators for adverse effects of obesity on the brain: A review.BioMedicine · 2021Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status, neurotrophic factor expression, and blood-brain barrier (BBB) disruption.
methodsTwenty-four healthy, untrained men (12 non-obese (mean 14.9% body fat) and 12 obese subjects (mean 29.8% body fat)) performed 20 min of continuous submaximal aerobic exercise at 85% maximal oxygen consumption. Blood sampling was performed to examine the oxidant-antioxidant status (reactive oxygen species (ROS) and superoxide dismutase (SOD)), neurotrophic factors (brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)), and BBB disruption (S100β and neuron-specific enolase) before and after acute exercise.
resultsThe obese group showed significantly higher pre-exercise serum ROS levels and significantly lower pre-exercise serum SOD levels than the non-obese group (
conclusionOur study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption, and it is assumed that oxidative stress was the main cause of this BBB disruption.
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