Evidence map›Paper›PMID 30356432›Full record

ArticleJournal of drug delivery2018

Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections.

James R Stegman, Jill K Badin, Kaitlyn A Biles, Thamar Etienne, Sogand Fartash-Naini, Ariel D Gordon, Zachary W Greeley, Benjamin W Harding, Ricardo J Mack, Danielle Masica and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

James R StegmanTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Jill K BadinTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Kaitlyn A BilesTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Thamar EtienneTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Sogand Fartash-NainiTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Ariel D GordonTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.ORCID 0000-0001-7529-3002
Zachary W GreeleyTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Benjamin W HardingTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Ricardo J MackTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.ORCID 0000-0003-1078-9888
Danielle MasicaTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.ORCID 0000-0001-7163-0147
Ashley N NelsonTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Amandeep K SamraTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Sarah E SmithTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Gabrielle P ThomasTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.ORCID 0000-0001-6827-9843
Haley J ZackTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Timothy J BrunkerDepartment of Chemistry, Towson University, Towson, MD 21252, USA.
Barry J MarguliesTowson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.ORCID 0000-0002-0042-0676
Towson University · USJohns Hopkins University · US

Funding

Long-Term Herpes Simplex Virus-1 Suppression by Continuous Acyclovir DeliveryR15AI084069 · NIAID · TOWSON UNIVERSITY · PI MARGULIES, BARRY JOSEPH · 2011 to 2011
$348k
NIAID NIH HHS R15 AI084069
6 · The paper itself

Abstract

Treatment for herpes simplex virus-1 and -2 (HSV-1 and -2) patients who suffer from recurrent outbreaks consists of multiple daily doses of the antiviral drugs acyclovir (ACV), penciclovir, or their more orally bioavailable derivatives valacyclovir or famciclovir. Drug troughs caused by missed doses may result in viral replication, which can generate drug-resistant mutants along with clinical sequelae. We developed a molecularly homogeneous mixture of ACV with the bioerodable polymer polycaprolactone. Through scanning electron microscopy, infrared spectroscopy, gel permeation chromatography, 1H NMR, and differential scanning calorimetry, our method of combining drug and polymer, termed Volatile Acid-Solvent Evaporation (VASE), does not compromise the integrity of polymer or drug. Furthermore, VASE creates materials that deliver therapeutic amounts of drug consistently for approximately two months. Devices with high enough drug loads diminish primary infection of HSV-1 in Vero cells to the same level as seen with a single dose of ACV. Our data will lead to further experiments in animal models, demonstrating efficacy in preventing reactivation of these viruses with a single intervention, and with other antiviral drugs amenable to such manipulation. Additionally, this type of treatment would leave no trace after its useful lifetime, as drug is released and polymer matrix is degraded

Identifiers

PMID30356432
PMCPMC6178155
OpenAlexW2892977836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.