ArticlePloS one2018
Integrated information in the EEG of preterm infants increases with family nurture intervention, age, and conscious state.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04233489 (Clinical Interventions to Mitigate Neurodevelopmental Risk), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Interventions to Mitigate Neurodevelopmental Risk
Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Markers of consciousness in infants: Towards a 'cluster-based' approach.Acta paediatrica (Oslo, Norway : 1992) · 2025Review
- Six weeks that changed the preterm infant brain: lessons learned from the Family Nurture Intervention randomized controlled trials.Frontiers in psychology · 2024Review
- Consciousness in the cradle: on the emergence of infant experience.Trends in cognitive sciences · 2023Review
- Information-Theoretic Approaches in EEG Correlates of Auditory Perceptual Awareness under Informational Masking.Biology · 2023Article
- Preschool-based mother-child emotional preparation program improves emotional connection, behavior regulation in the home and classroom: a randomized controlled trial.Frontiers in child and adolescent psychiatry · 2023Article
- Different Approximation Methods for Calculation of Integrated Information Coefficient in the Brain during Instrumental Learning.Brain sciences · 2022Article
- Emergence of Integrated Information at Macro Timescales in Real Neural Recordings.Entropy (Basel, Switzerland) · 2022Article
- Effects of Family Nurture Intervention in the NICU on Theory of Mind Abilities in Children Born Very Preterm: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2022Article
- [Touch Medicine - a complementary therapeutic approach exemplified by the treatment of depression].Deutsche medizinische Wochenschrift (1946) · 2022Article
- Integrated world modeling theory expanded: Implications for the future of consciousness.Frontiers in computational neuroscience · 2022Article
- Consciousness and complexity: a consilience of evidence.Neuroscience of consciousness · 2021Review
- Effects of Early Intervention on Visual Function in Preterm Infants: A Randomized Controlled Trial.Frontiers in pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A putative quantifier of consciousness, integrated information, was applied to preterm infant EEG data after novel pre-processing. Integrated information had a non-random structure as a function of the time lag over which it was computed. For most lags, it increased with age in early life, but even more so in infants exposed to Family Nurture Intervention (FNI), providing further evidence that FNI advances brain maturation in preterm infants. Also, it discriminated between conscious states (awake, REM sleep, NREM sleep), providing empirical support for the Integrated Information Theory of Consciousness in human infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.