ArticlePLoS neglected tropical diseases2018
Spatial heterogeneity of hemorrhagic fever with renal syndrome is driven by environmental factors and rodent community composition.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Influence of Host and Landscape-Associated Factors in the Infection and Transmission of Pathogens: The Case of Directly Transmitted Virus in Mammals.Veterinary medicine and science · 2025Pooled it
- Land-cover, land-use and human hantavirus infection risk: a systematic review.Pathogens and global health · 2024Pooled it
- Dual seasonal pattern for hemorrhagic fever with renal syndrome and its potential determinants in China.The Science of the total environment · 2023Pooled it
- Regional heterogeneity of spatial-temporal characteristics and meteorological-environmental driving factors of hemorrhagic fever with renal syndrome in China.One health (Amsterdam, Netherlands) · 2026Article
- Urbanization influences hemorrhagic fever with renal syndrome transmission: 34-year evidence from China's national surveillance.Infectious Disease Modelling · 2026Article
- Spatiotemporal pattern of hemorrhagic fever with renal syndrome and driving factors in Shandong Province of China, 2018-2024.PLoS neglected tropical diseases · 2026Article
- Epidemiological characteristics and spatiotemporal heterogeneity of hemorrhagic fever with renal syndrome in the Jiaodong Peninsula region, China, 2019-2025.Frontiers in public health · 2026Article
- Longitudinal study of Orthohantavirus hantanense in Apodemus agrarius and disease risk assessment in the Republic of Korea during 2000-2019.Scientific reports · 2025Article
- Using empirical dynamic modeling to identify the impact of meteorological factors on hemorrhagic fever with renal syndrome in Weifang, Northeastern China, from 2011 to 2020.PLoS neglected tropical diseases · 2024Article
- Urbanization-Related Environmental Factors and Hemorrhagic Fever with Renal Syndrome: A Review Based on Studies Taken in China.International journal of environmental research and public health · 2023Review
- Identification and characterization of codon usage pattern and influencing factors in HFRS-causing hantaviruses.Frontiers in immunology · 2023Article
- Spatiotemporal association of rapid urbanization and water-body distribution on hemorrhagic fever with renal syndrome: A case study in the city of Xi'an, China.PLoS neglected tropical diseases · 2022Article
- Epidemiological Characteristics and Regional Risk Prediction of Hemorrhagic Fever with Renal Syndrome in Shandong Province, China.International journal of environmental research and public health · 2021Article
- Epidemiology of hemorrhagic fever with renal syndrome in Tai'an area.Scientific reports · 2021Article
- Misdiagnosis of scrub typhus as hemorrhagic fever with renal syndrome and potential co-infection of both diseases in patients in Shandong Province, China, 2013-2014.PLoS neglected tropical diseases · 2021Article
- Effects and interaction of meteorological factors on hemorrhagic fever with renal syndrome incidence in Huludao City, northeastern China, 2007-2018.PLoS neglected tropical diseases · 2021Article
- Research Advances of Leptotrombidium scutellare in China.The Korean journal of parasitology · 2021Review
- A case-control study on the risk factors for hemorrhagic fever with renal syndrome.BMC infectious diseases · 2020Article
- Analysis of Hemorrhagic Fever With Renal Syndrome Using Wavelet Tools in Mainland China, 2004-2019.Frontiers in public health · 2020Article
- Epidemiological and time series analysis of haemorrhagic fever with renal syndrome from 2004 to 2017 in Shandong Province, China.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused mainly by two hantaviruses in China: Hantaan virus and Seoul virus. Environmental factors can significantly affect the risk of contracting hantavirus infections, primarily through their effects on rodent population dynamics and human-rodent contact. We aimed to clarify the environmental risk factors favoring rodent-to-human transmission to provide scientific evidence for developing effective HFRS prevention and control strategies. The 10-year (2006-2015) field surveillance data from the rodent hosts for hantavirus, the epidemiological and environmental data extracted from satellite images and meteorological stations, rodent-to-human transmission rates and impacts of the environment on rodent community composition were used to quantify the relationships among environmental factors, rodent species and HFRS occurrence. The study included 709 cases of HFRS. Rodent species in Chenzhou, a hantavirus hotspot, comprise mainly Rattus norvegicus, Mus musculus, R. flavipectus and some other species (R. losea and Microtus fortis calamorum). The rodent species played different roles across the various land types we examined, but all of them were associated with transmission risks. Some species were associated with HFRS occurrence risk in forest and water bodies. R. norvegicus and R. flavipectus were associated with risk of HFRS incidence in grassland, whereas M. musculus and R. flavipectus were associated with this risk in built-on land. The rodent community composition was also associated with environmental variability. The predictive risk models based on these significant factors were validated by a good-fit model, where: cultivated land was predicted to represent the highest risk for HFRS incidence, which accords with the statistics for HFRS cases in 2014-2015. The spatial heterogeneity of HFRS disease may be influenced by rodent community composition, which is associated with local environmental conditions. Therefore, future work should focus on preventing HFRS is moist, warm environments.
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